Human Recombinant SERPINB1 protein, His Tag (V2LY-0526-LY6720)

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Datasheet
SDS
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Basic Information

Expressed Host
Baculovirus-Insect Cells
Protein Species
Human
Tag
His Tag
Protein Construction
This product is Human Recombinant SERPINB1 protein, His Tag consist of Amino Acid: 1-379 and predicts a molecular mass of 44 kDa.
Molecule Mass
44 kDa
Sequence
Amino Acid: 1-379
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>90% as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Format
Lyophilized
Reconstitution
Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.
Buffer
Lyophilized from sterile HEPES, NaCl
Preservative
None
Storage
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
More Infomation

Target

Full Name
Serpin Family B Member 1
Function
Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis (PubMed:30692621).
Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3 (PubMed:11747453, PubMed:30692621).
Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity (PubMed:23269243).
During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621).
When secreted, promotes the proliferation of beta-cells via its protease inhibitory function (PubMed:26701651).
Biological Process
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process type B pancreatic cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Secreted
Cytoplasm
Cytolytic granule
Early endosome
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

SERPINB1 Matched Antibody Pair (1066) (CAT#: APMAB-1066LY)

SERPINB1 Matched Antibody Pair (1067) (CAT#: APMAB-1067LY)

SERPINB1 Matched Antibody Pair (1068) (CAT#: APMAB-1068LY)

Antibody Pairs

SERPINB1 Matched Antibody Pair (1066) (CAT#: APMAB-1066LY)

SERPINB1 Matched Antibody Pair (1067) (CAT#: APMAB-1067LY)

SERPINB1 Matched Antibody Pair (1068) (CAT#: APMAB-1068LY)

Related Products

Mouse Anti-SERPINB1 Recombinant Antibody (CBXS-4953) (CAT#: CBMAB-S2175-CQ)

Mouse Anti-SERPINB1 Recombinant Antibody (CBXS-4983) (CAT#: CBMAB-S2205-CQ)

Mouse Anti-SERPINB1 Recombinant Antibody (CBXS-4478) (CAT#: CBMAB-S1720-CQ)

SERPINB1 Matched Antibody Pair (1066) (CAT#: APMAB-1066LY)

Mouse Anti-SERPINB1 Recombinant Antibody (CBXS-1136) (CAT#: CBMAB-S4020-CQ)

SERPINB1 Matched Antibody Pair (1068) (CAT#: APMAB-1068LY)

Mouse Anti-SERPINB1 Recombinant Antibody (4D7) (CAT#: CBMAB-A7996-LY)

Mouse Anti-SERPINB1 Recombinant Antibody (4A7) (CAT#: CBMAB-A7995-LY)

Mouse Anti-SERPINB1 Recombinant Antibody (CBXS-0963) (CAT#: CBMAB-S3872-CQ)

SERPINB1 Matched Antibody Pair (1067) (CAT#: APMAB-1067LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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