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Mouse Anti-SERPINB5 Recombinant Antibody (CBXS-4665) (CBMAB-S0244-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4665
Antibody Isotype
IgG2b
Application
WB, ELISA, IF

Basic Information

Immunogen
Mbinant Maspin (1-375aa) purified from E. coli
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
serpin peptidase inhibitor, clade B (ovalbumin), member 5
Introduction
SERPINB5 (Serpin Family B Member 5) is a Protein Coding gene. Diseases associated with SERPINB5 include Syringoma and Bone Squamous Cell Carcinoma. Among its related pathways are Direct p53 effectors and DNA Damage Response. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB1.
Entrez Gene ID
5268
UniProt ID
P36952
Alternative Names
Serpin Family B Member 5; Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 5; Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 5; Protease Inhibitor 5 (Maspin); Peptidase Inhibitor 5; Maspin; PI-5; PI5; Serpin B5;
Function
Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Biological Process
Biological Process extracellular matrix organizationIEA:Ensembl
Biological Process morphogenesis of an epitheliumIEA:Ensembl
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process prostate gland morphogenesisIEA:Ensembl
Biological Process regulation of epithelial cell proliferationIEA:Ensembl
Cellular Location
Secreted, extracellular space
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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