SERPINB5
SERPINB5 (Serpin Family B Member 5) is a Protein Coding gene. Diseases associated with SERPINB5 include Syringoma and Bone Squamous Cell Carcinoma. Among its related pathways are Direct p53 effectors and DNA Damage Response. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB1.
Full Name
serpin peptidase inhibitor, clade B (ovalbumin), member 5
Function
Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Biological Process
Biological Process extracellular matrix organizationIEA:Ensembl
Biological Process morphogenesis of an epitheliumIEA:Ensembl
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process prostate gland morphogenesisIEA:Ensembl
Biological Process regulation of epithelial cell proliferationIEA:Ensembl
Biological Process morphogenesis of an epitheliumIEA:Ensembl
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process prostate gland morphogenesisIEA:Ensembl
Biological Process regulation of epithelial cell proliferationIEA:Ensembl
Cellular Location
Secreted, extracellular space
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Anti-SERPINB5 antibodies
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Target: SERPINB5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1F7
Application*: WB, E
Target: SERPINB5
Host: Mouse
Specificity: Human
Clone: CBXS-2787
Application*: E, IF, WB
Target: SERPINB5
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-1758
Application*: WB, IP
Target: SERPINB5
Host: Mouse
Specificity: Human
Clone: CBXS-0244
Application*: WB, IC, P, C, E
Target: SERPINB5
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-0243
Application*: E, IF, R, WB
Target: SERPINB5
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-0242
Application*: E, IP, WB
Target: SERPINB5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-0241
Application*: E, WB
Target: SERPINB5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4665
Application*: WB, E, IF
Target: SERPINB5
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYM-3119
Application*: E, IF, WB
Target: SERPINB5
Sensitivity: 0.031 ng/mL
Detection Range: 0.06-18 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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