Mouse Anti-SERPIND1 Recombinant Antibody (CBFYH-2750) (CBMAB-H3811-FY)

Name: Mouse Anti-SERPIND1 Recombinant Antibody (CBFYH-2750)
SKU: CBMAB-H3811-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBFYH-2750

Application

WB, ELISA

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Serpin Family D Member 1

Introduction

This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency.

Entrez Gene ID

3053

UniProt ID

P05546

Alternative Names

Serpin Family D Member 1; Serine (Or Cysteine) Proteinase Inhibitor, Clade D (Heparin Cofactor), Member 1; Serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1; Protease Inhibitor Leuserpin-2; Heparin Cofactor II; Heparin Cofactor 2; Serpin D1; HCF2; HLS2

Function

Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.

Biological Process

Biological Process blood coagulationIEA:UniProtKB-KW
Biological Process chemotaxisIEA:UniProtKB-KW
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

endoplasmic reticulum lumen
extracellular exosome
extracellular region
extracellular space

Involvement in disease

Thrombophilia due to heparin cofactor 2 deficiency (THPH10):
A hemostatic disorder characterized by a tendency to recurrent thrombosis.

PTM

Phosphorylated by FAM20C in the extracellular medium.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

SERPIND1 Matched Antibody Pair (1072) (CAT#: APMAB-1072LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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