SERPIND1

This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq, Jul 2015]
Full Name
Serpin Family D Member 1
Function
Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.
Biological Process
Biological Process blood coagulationIEA:UniProtKB-KW
Biological Process chemotaxisIEA:UniProtKB-KW
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
endoplasmic reticulum lumen
extracellular exosome
extracellular region
extracellular space
Involvement in disease
Thrombophilia due to heparin cofactor 2 deficiency (THPH10):
A hemostatic disorder characterized by a tendency to recurrent thrombosis.
PTM
Phosphorylated by FAM20C in the extracellular medium.
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Anti-SERPIND1 antibodies

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SERPIND1 Matched Antibody Pair (1072) (APMAB-1072LY)

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Target: SERPIND1
Specificity: Human
Datasheet SDS

Mouse Anti-SERPIND1 Recombinant Antibody (CBXS-1803) (CBMAB-S4616-CQ)

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Target: SERPIND1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-1803
Application*: WB, IP
Datasheet SDS

Mouse Anti-SERPIND1 Recombinant Antibody (CBXS-1146) (CBMAB-S4029-CQ)

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Target: SERPIND1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1146
Application*: P
Datasheet SDS

Rabbit Anti-SERPIND1 Recombinant Antibody (CBXS-1069) (CBMAB-S3960-CQ)

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Target: SERPIND1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1069
Application*: P
Datasheet SDS

Mouse Anti-SERPIND1 Recombinant Antibody (CBXS-0252) (CBMAB-S3229-CQ)

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Target: SERPIND1
Host: Mouse
Specificity: Rat
Clone: CBXS-0252
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-SERPIND1 Recombinant Antibody (CBXS-0251) (CBMAB-S3228-CQ)

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Target: SERPIND1
Host: Mouse
Specificity: Human
Clone: CBXS-0251
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-SERPIND1 Recombinant Antibody (CBXS-0250) (CBMAB-S3227-CQ)

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Target: SERPIND1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-0250
Application*: E, WB
Datasheet SDS

Rabbit Anti-SERPIND1 Recombinant Antibody (CBXS-5271) (CBMAB-S2485-CQ)

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Target: SERPIND1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-5271
Application*: P
Datasheet SDS

Mouse Anti-SERPIND1 Recombinant Antibody (CBXS-5243) (CBMAB-S2458-CQ)

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Target: SERPIND1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5243
Application*: P
Datasheet SDS

Mouse Anti-SERPIND1 Recombinant Antibody (CBXS-4795) (CBMAB-S2021-CQ)

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Target: SERPIND1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4795
Application*: E
Datasheet SDS

Rabbit Anti-SERPIND1 Recombinant Antibody (CBXS-4292) (CBMAB-S1538-CQ)

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Target: SERPIND1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXS-4292
Application*: WB, E, IP
Datasheet SDS

Mouse Anti-SERPIND1 Recombinant Antibody (CBXS-5854) (CBMAB-S0708-CQ)

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Target: SERPIND1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-5854
Application*: E, P, WB
Datasheet SDS

Mouse Anti-SERPIND1 Recombinant Antibody (CBFYH-2750) (CBMAB-H3811-FY)

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Target: SERPIND1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-2750
Application*: WB, E
Datasheet SDS

Mouse Anti-SERPIND1 Recombinant Antibody (CBFYH-2749) (CBMAB-H3810-FY)

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Target: SERPIND1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYH-2749
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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