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Mouse Anti-SERPIND1 Recombinant Antibody (CBXS-4795) (CBMAB-S2021-CQ)

This product is a mouse antibody that recognizes SERPIND1. The antibody CBXS-4795 can be used for immunoassay techniques such as: ELISA.
See all SERPIND1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4795
Antibody Isotype
IgG1
Application
ELISA

Basic Information

Immunogen
Recombinant Human SerpinD1/HC2 Protein
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Serpin Family D Member 1
Introduction
This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency.
Entrez Gene ID
3053
UniProt ID
P05546
Alternative Names
Serpin Family D Member 1; Serine (Or Cysteine) Proteinase Inhibitor, Clade D (Heparin Cofactor), Member 1; Serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1; Protease Inhibitor Leuserpin-2; Heparin Cofactor II; Heparin Cofactor 2; Serpin D1; HCF2; HLS2;
Function
Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.
Biological Process
Biological Process blood coagulationIEA:UniProtKB-KW
Biological Process chemotaxisIEA:UniProtKB-KW
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
endoplasmic reticulum lumen
extracellular exosome
extracellular region
extracellular space
Involvement in disease
Thrombophilia due to heparin cofactor 2 deficiency (THPH10):
A hemostatic disorder characterized by a tendency to recurrent thrombosis.
PTM
Phosphorylated by FAM20C in the extracellular medium.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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