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Mouse Anti-SETD4 Recombinant Antibody (CBXS-2215) (CBMAB-S4977-CQ)

This product is a mouse antibody that recognizes SETD4. The antibody CBXS-2215 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all SETD4 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBXS-2215
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SET Domain Containing 4
Introduction
SETD4 (SET Domain Containing 4) is a Protein Coding gene. Among its related pathways are PKMTs methylate histone lysines. Gene Ontology (GO) annotations related to this gene include methyltransferase activity. An important paralog of this gene is SETD3.
Entrez Gene ID
Human54093
Mouse224440
Rat245975
UniProt ID
HumanQ9NVD3
MouseP58467
RatB0BN36
Alternative Names
SET Domain Containing 4; C21orf18; C21orf27; Chromosome 21 Open Reading Frame 27; Chromosome 21 Open Reading Frame 18; SET Domain-Containing Protein 4; EC 2.1.1.-;
Function
Histone-lysine N-methyltransferase that acts as a regulator of cell proliferation, cell differentiation and inflammatory response (PubMed:31308046).
Regulates the inflammatory response by mediating mono- and dimethylation of 'Lys-4' of histone H3 (H3K4me1 and H3K4me2, respectively), leading to activate the transcription of pro-inflammatory cytokines IL6 and TNF-alpha (By similarity).
Also involved in the regulation of stem cell quiescence by catalyzing the trimethylation of 'Lys-20' of histone H4 (H4K20me3), thereby promoting heterochromatin formation (PubMed:31308046).
Involved in proliferation, migration, paracrine and myogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) (By similarity).
Biological Process
Biological Process histone H3-K4 dimethylationISS:UniProtKB
Biological Process histone H3-K4 monomethylationISS:UniProtKB
Biological Process histone H4-K20 trimethylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process inflammatory responseIEA:UniProtKB-KW
Biological Process peptidyl-lysine monomethylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process peptidyl-lysine trimethylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of inflammatory responseISS:UniProtKB
Biological Process positive regulation of interleukin-6 productionISS:UniProtKB
Biological Process positive regulation of tumor necrosis factor productionISS:UniProtKB
Biological Process regulation of cell proliferation in bone marrowISS:UniProtKB
Cellular Location
Cytoplasm, cytosol
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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