Mouse Anti-SETD4 Recombinant Antibody (CBXS-2215) (CBMAB-S4977-CQ)

Name: Mouse Anti-SETD4 Recombinant Antibody (CBXS-2215)
SKU: CBMAB-S4977-CQ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBXS-2215

Application

WB, IP, IF, ELISA

Specificity

Mouse, Rat, Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SET Domain Containing 4

Introduction

SETD4 (SET Domain Containing 4) is a Protein Coding gene. Among its related pathways are PKMTs methylate histone lysines. Gene Ontology (GO) annotations related to this gene include methyltransferase activity. An important paralog of this gene is SETD3.

Entrez Gene ID

Human	54093
Mouse	224440
Rat	245975

UniProt ID

Human	Q9NVD3
Mouse	P58467
Rat	B0BN36

Alternative Names

SET Domain Containing 4; C21orf18; C21orf27; Chromosome 21 Open Reading Frame 27; Chromosome 21 Open Reading Frame 18; SET Domain-Containing Protein 4; EC 2.1.1.-;

Function

Histone-lysine N-methyltransferase that acts as a regulator of cell proliferation, cell differentiation and inflammatory response (PubMed:31308046).
Regulates the inflammatory response by mediating mono- and dimethylation of 'Lys-4' of histone H3 (H3K4me1 and H3K4me2, respectively), leading to activate the transcription of pro-inflammatory cytokines IL6 and TNF-alpha (By similarity).
Also involved in the regulation of stem cell quiescence by catalyzing the trimethylation of 'Lys-20' of histone H4 (H4K20me3), thereby promoting heterochromatin formation (PubMed:31308046).
Involved in proliferation, migration, paracrine and myogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) (By similarity).

Biological Process

Biological Process histone H3-K4 dimethylationISS:UniProtKB
Biological Process histone H3-K4 monomethylationISS:UniProtKB
Biological Process histone H4-K20 trimethylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process inflammatory responseIEA:UniProtKB-KW
Biological Process peptidyl-lysine monomethylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process peptidyl-lysine trimethylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of inflammatory responseISS:UniProtKB
Biological Process positive regulation of interleukin-6 productionISS:UniProtKB
Biological Process positive regulation of tumor necrosis factor productionISS:UniProtKB
Biological Process regulation of cell proliferation in bone marrowISS:UniProtKB

Cellular Location

Cytoplasm, cytosol
Nucleus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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