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Mouse Anti-SETD7 Recombinant Antibody (CBXS-0285) (CBMAB-S3260-CQ)

This product is a mouse antibody that recognizes SETD7. The antibody CBXS-0285 can be used for immunoassay techniques such as: ELISA, WB.
See all SETD7 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0285
Antibody Isotype
IgG2b
Application
ELISA, WB

Basic Information

Immunogen
Recombinant human SETD7 amino acids 1-366 purified from E.coli
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SET Domain Containing Lysine Methyltransferase 7
Introduction
SETD7 (SET Domain Containing Lysine Methyltransferase 7) is a Protein Coding gene. Among its related pathways are PKMTs methylate histone lysines and Chromatin organization. Gene Ontology (GO) annotations related to this gene include p53 binding and protein-lysine N-methyltransferase activity.
Entrez Gene ID
80854
UniProt ID
Q8WTS6
Alternative Names
SET Domain Containing Lysine Methyltransferase 7; Histone H3-K4 Methyltransferase SETD7; SET Domain-Containing Protein 7; Lysine N-Methyltransferase 7; H3-K4-HMTase SETD7; SET7/9; KMT7;
Function
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3 (PubMed:11779497, PubMed:11850410, PubMed:12588998, PubMed:12540855, PubMed:16141209).
H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:12588998, PubMed:12540855, PubMed:16141209).
Plays a central role in the transcriptional activation of genes such as collagenase or insulin (PubMed:16141209, PubMed:12588998).
Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription (PubMed:16141209).
Has also methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins (PubMed:15099517, PubMed:35210392, PubMed:15525938, PubMed:16415881).
Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II (PubMed:15099517, PubMed:16415881).
Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation (PubMed:17108971, PubMed:15525938, PubMed:16415881).
Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS (By similarity).
Biological Process
Biological Process cellular response to DNA damage stimulusManual Assertion Based On ExperimentIDA:MGI
Biological Process chromatin organization1 PublicationNAS:UniProtKB
Biological Process heterochromatin organizationManual Assertion Based On ExperimentIDA:MGI
Biological Process histone lysine methylationIEA:InterPro
Biological Process peptidyl-lysine dimethylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process peptidyl-lysine monomethylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of DNA-templated transcriptionIEA:InterPro
Biological Process regulation of histone H3-K9 methylationIEA:Ensembl
Cellular Location
Nucleus
Chromosome
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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