SETD7
SETD7 (SET Domain Containing Lysine Methyltransferase 7) is a Protein Coding gene. Among its related pathways are PKMTs methylate histone lysines and Chromatin organization. Gene Ontology (GO) annotations related to this gene include p53 binding and protein-lysine N-methyltransferase activity.
Full Name
SET Domain Containing Lysine Methyltransferase 7
Function
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3 (PubMed:11779497, PubMed:11850410, PubMed:12588998, PubMed:12540855, PubMed:16141209).
H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:12588998, PubMed:12540855, PubMed:16141209).
Plays a central role in the transcriptional activation of genes such as collagenase or insulin (PubMed:16141209, PubMed:12588998).
Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription (PubMed:16141209).
Has also methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins (PubMed:15099517, PubMed:35210392, PubMed:15525938, PubMed:16415881).
Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II (PubMed:15099517, PubMed:16415881).
Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation (PubMed:17108971, PubMed:15525938, PubMed:16415881).
Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS (By similarity).
H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:12588998, PubMed:12540855, PubMed:16141209).
Plays a central role in the transcriptional activation of genes such as collagenase or insulin (PubMed:16141209, PubMed:12588998).
Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription (PubMed:16141209).
Has also methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins (PubMed:15099517, PubMed:35210392, PubMed:15525938, PubMed:16415881).
Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II (PubMed:15099517, PubMed:16415881).
Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation (PubMed:17108971, PubMed:15525938, PubMed:16415881).
Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS (By similarity).
Biological Process
Biological Process cellular response to DNA damage stimulusManual Assertion Based On ExperimentIDA:MGI
Biological Process chromatin organization1 PublicationNAS:UniProtKB
Biological Process heterochromatin organizationManual Assertion Based On ExperimentIDA:MGI
Biological Process histone lysine methylationIEA:InterPro
Biological Process peptidyl-lysine dimethylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process peptidyl-lysine monomethylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of DNA-templated transcriptionIEA:InterPro
Biological Process regulation of histone H3-K9 methylationIEA:Ensembl
Biological Process chromatin organization1 PublicationNAS:UniProtKB
Biological Process heterochromatin organizationManual Assertion Based On ExperimentIDA:MGI
Biological Process histone lysine methylationIEA:InterPro
Biological Process peptidyl-lysine dimethylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process peptidyl-lysine monomethylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of DNA-templated transcriptionIEA:InterPro
Biological Process regulation of histone H3-K9 methylationIEA:Ensembl
Cellular Location
Nucleus
Chromosome
Chromosome
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Anti-SETD7 antibodies
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CompareTarget: SETD7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: s4E5
Application*: WB, E, P, F, CI, IF
Target: SETD7
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat, Monkey
Clone: CBT2015
Application*: WB, F
Target: SETD7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Monkey
Clone: CBT4089
Application*: WB, IH
Target: SETD7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5B4
Application*: WB, E
Target: SETD7
Host: Mouse
Specificity: Human
Clone: CBXS-3267
Application*: E, F, IC, IF, WB
Target: SETD7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1535
Application*: WB, IP
Target: SETD7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1049
Application*: E
Target: SETD7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-0965
Application*: SE, P, E, WB, IF, WB
Target: SETD7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0287
Application*: IC, IF, IP, WB
Target: SETD7
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-0286
Application*: E, WB, P
Target: SETD7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-0285
Application*: E, WB
Target: SETD7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-0284
Application*: WB
Target: SETD7
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-0283
Application*: E, F, P, WB
Target: SETD7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5B4
Application*: E, IF, P, WB
Target: SETD7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4537
Application*: F, WB
Target: SETD7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat, Dog
Clone: CBXS-4474
Application*: WB, F, IH, IF, P
Target: SETD7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4316
Application*: DB, WB
Target: SETD7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3780
Application*: WB
Target: SETD7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBXS-5995
Application*: WB
Target: SETD7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-5867
Application*: E
Target: SETD7
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-5729
Application*: F, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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