SETD7

SETD7 (SET Domain Containing Lysine Methyltransferase 7) is a Protein Coding gene. Among its related pathways are PKMTs methylate histone lysines and Chromatin organization. Gene Ontology (GO) annotations related to this gene include p53 binding and protein-lysine N-methyltransferase activity.
Full Name
SET Domain Containing Lysine Methyltransferase 7
Function
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3 (PubMed:11779497, PubMed:11850410, PubMed:12588998, PubMed:12540855, PubMed:16141209).
H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:12588998, PubMed:12540855, PubMed:16141209).
Plays a central role in the transcriptional activation of genes such as collagenase or insulin (PubMed:16141209, PubMed:12588998).
Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription (PubMed:16141209).
Has also methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins (PubMed:15099517, PubMed:35210392, PubMed:15525938, PubMed:16415881).
Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II (PubMed:15099517, PubMed:16415881).
Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation (PubMed:17108971, PubMed:15525938, PubMed:16415881).
Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS (By similarity).
Biological Process
Biological Process cellular response to DNA damage stimulusManual Assertion Based On ExperimentIDA:MGI
Biological Process chromatin organization1 PublicationNAS:UniProtKB
Biological Process heterochromatin organizationManual Assertion Based On ExperimentIDA:MGI
Biological Process histone lysine methylationIEA:InterPro
Biological Process peptidyl-lysine dimethylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process peptidyl-lysine monomethylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of DNA-templated transcriptionIEA:InterPro
Biological Process regulation of histone H3-K9 methylationIEA:Ensembl
Cellular Location
Nucleus
Chromosome
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Anti-SETD7 antibodies

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Mouse Anti-SETD7 Recombinant Antibody (s4E5) (CBMAB-S0360-CQ)

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Target: SETD7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: s4E5
Application*: WB, E, P, F, CI, IF
Datasheet SDS

Mouse Anti-SETD7 Recombinant Antibody (CBT2015) (V2LY-0625-LY1261)

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Target: SETD7
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat, Monkey
Clone: CBT2015
Application*: WB, F
Datasheet SDS

Mouse Anti-SETD7 Recombinant Antibody (CBT4089) (V2LY-0625-LY1260)

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Target: SETD7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Monkey
Clone: CBT4089
Application*: WB, IH
Datasheet SDS

Mouse Anti-SETD7 Recombinant Antibody (5B4) (CBMAB-A8015-LY)

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Target: SETD7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5B4
Application*: WB, E
Datasheet SDS

Mouse Anti-SETD7 Recombinant Antibody (CBXS-3267) (CBMAB-S6007-CQ)

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Target: SETD7
Host: Mouse
Specificity: Human
Clone: CBXS-3267
Application*: E, F, IC, IF, WB
Datasheet SDS

Rabbit Anti-SETD7 Recombinant Antibody (CBXS-1535) (CBMAB-S4385-CQ)

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Target: SETD7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1535
Application*: WB, IP
Datasheet SDS

Rabbit Anti-SETD7 Recombinant Antibody (CBXS-1049) (CBMAB-S3942-CQ)

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Target: SETD7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1049
Application*: E
Datasheet SDS

Mouse Anti-SETD7 Recombinant Antibody (CBXS-0965) (CBMAB-S3874-CQ)

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Target: SETD7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-0965
Application*: SE, P, E, WB, IF, WB
Datasheet SDS

Mouse Anti-SETD7 Recombinant Antibody (CBXS-0287) (CBMAB-S3262-CQ)

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Target: SETD7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0287
Application*: IC, IF, IP, WB
Datasheet SDS

Mouse Anti-SETD7 Recombinant Antibody (CBXS-0286) (CBMAB-S3261-CQ)

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Target: SETD7
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-0286
Application*: E, WB, P
Datasheet SDS

Mouse Anti-SETD7 Recombinant Antibody (CBXS-0285) (CBMAB-S3260-CQ)

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Target: SETD7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-0285
Application*: E, WB
Datasheet SDS

Rabbit Anti-SETD7 (N-Term) Recombinant Antibody (CBXS-0284) (CBMAB-S3259-CQ)

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Target: SETD7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-0284
Application*: WB
Datasheet SDS

Mouse Anti-SETD7 (AA 1-366) Recombinant Antibody (CBXS-0283) (CBMAB-S3258-CQ)

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Target: SETD7
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-0283
Application*: E, F, P, WB
Datasheet SDS

Mouse Anti-SETD7 Recombinant Antibody (5B4) (CBMAB-S2868-CQ)

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Target: SETD7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5B4
Application*: E, IF, P, WB
Datasheet SDS

Mouse Anti-SETD7 Recombinant Antibody (CBXS-4537) (CBMAB-S1777-CQ)

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Target: SETD7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4537
Application*: F, WB
Datasheet SDS

Mouse Anti-SETD7 Recombinant Antibody (CBXS-4474) (CBMAB-S1716-CQ)

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Target: SETD7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat, Dog
Clone: CBXS-4474
Application*: WB, F, IH, IF, P
Datasheet SDS

Mouse Anti-SETD7 Recombinant Antibody (CBXS-4316) (CBMAB-S1561-CQ)

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Target: SETD7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4316
Application*: DB, WB
Datasheet SDS

Mouse Anti-SETD7 Recombinant Antibody (CBXS-3780) (CBMAB-S1052-CQ)

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Target: SETD7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3780
Application*: WB
Datasheet SDS

Rabbit Anti-SETD7 Recombinant Antibody (CBXS-5995) (CBMAB-S0841-CQ)

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Target: SETD7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBXS-5995
Application*: WB
Datasheet SDS

Mouse Anti-SETD7 Recombinant Antibody (CBXS-5867) (CBMAB-S0719-CQ)

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Target: SETD7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-5867
Application*: E
Datasheet SDS

Mouse Anti-SETD7 Recombinant Antibody (CBXS-5729) (CBMAB-S0592-CQ)

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Target: SETD7
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-5729
Application*: F, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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