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Rabbit Anti-SF3B3 Recombinant Antibody (CBXS-1449) (CBMAB-S4307-CQ)

This product is a rabbit antibody that recognizes SF3B3. The antibody CBXS-1449 can be used for immunoassay techniques such as: WB, IP, IHC-P, IF.
See all SF3B3 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBXS-1449
Antibody Isotype
IgG
Application
WB, IP, IHC-P, IF

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
splicing factor 3b, subunit 3, 130kDa
Introduction
This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.
Entrez Gene ID
Human23450
Mouse101943
Rat292019
UniProt ID
HumanQ15393
MouseQ921M3
RatB5DF12
Alternative Names
Splicing Factor 3b Subunit 3; Spliceosome-Associated Protein 130; SAP 130; SF3b130; STAF130; SAP130; Pre-MRNA Splicing Factor SF3b, 130 KDa Subunit;
Function
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome (PubMed:10490618, PubMed:10882114, PubMed:27720643, PubMed:28781166).
SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937).
May also be involved in the assembly of the 'E' complex (PubMed:10882114).
Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077).
Biological Process
Biological Process histone H3 acetylation1 PublicationIC:ComplexPortal
Biological Process monoubiquitinated histone deubiquitinationManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process monoubiquitinated histone H2A deubiquitinationManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of protein catabolic processManual Assertion Based On ExperimentIDA:CACAO
Biological Process positive regulation of DNA-templated transcription1 PublicationIC:ComplexPortal
Biological Process regulation of DNA repair1 PublicationIC:ComplexPortal
Biological Process regulation of RNA splicing1 PublicationIC:ComplexPortal
Biological Process RNA splicing1 PublicationIC:UniProtKB
Biological Process RNA splicing, via transesterification reactionsManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process U2-type prespliceosome assembly1 PublicationIC:ComplexPortal
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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