Mouse Anti-SFN Recombinant Antibody (3C3) (CBMAB-1210-LY)

Name: Mouse Anti-SFN Recombinant Antibody (3C3)
SKU: CBMAB-1210-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3C3

Application

WB, IHC-P

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

SFN

Introduction

This gene encodes a cell cycle checkpoint protein. The encoded protein binds to translation and initiation factors and functions as a regulator of mitotic translation. In response to DNA damage this protein plays a role in preventing DNA errors during mitosis. Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.

Entrez Gene ID

2810

UniProt ID

P31947

Alternative Names

YWHAS

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
p53-regulated inhibitor of G2/M progression.

Biological Process

Biological Process establishment of skin barrierISS:UniProtKB
Biological Process intrinsic apoptotic signaling pathway in response to DNA damageManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process keratinizationIEA:Ensembl
Biological Process keratinocyte developmentIEA:Ensembl
Biological Process keratinocyte proliferationIEA:Ensembl
Biological Process negative regulation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process negative regulation of keratinocyte proliferationIEA:Ensembl
Biological Process negative regulation of protein kinase activityManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of stem cell proliferationIEA:Ensembl
Biological Process positive regulation of cell growthIEA:Ensembl
Biological Process positive regulation of epidermal cell differentiationISS:UniProtKB
Biological Process positive regulation of protein export from nucleusIEA:Ensembl
Biological Process protein localizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of cyclin-dependent protein serine/threonine kinase activityIEA:Ensembl
Biological Process regulation of epidermal cell divisionISS:UniProtKB
Biological Process release of cytochrome c from mitochondriaManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process stem cell proliferationIEA:Ensembl

Cellular Location

Cytoplasm
Nucleus
Secreted
May be secreted by a non-classical secretory pathway.

PTM

Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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