SFN

This gene encodes a cell cycle checkpoint protein. The encoded protein binds to translation and initiation factors and functions as a regulator of mitotic translation. In response to DNA damage this protein plays a role in preventing DNA errors during mitosis.
Full Name
SFN
Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
p53-regulated inhibitor of G2/M progression.
Biological Process
Biological Process establishment of skin barrierISS:UniProtKB
Biological Process intrinsic apoptotic signaling pathway in response to DNA damageManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process keratinizationIEA:Ensembl
Biological Process keratinocyte developmentIEA:Ensembl
Biological Process keratinocyte proliferationIEA:Ensembl
Biological Process negative regulation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process negative regulation of keratinocyte proliferationIEA:Ensembl
Biological Process negative regulation of protein kinase activityManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of stem cell proliferationIEA:Ensembl
Biological Process positive regulation of cell growthIEA:Ensembl
Biological Process positive regulation of epidermal cell differentiationISS:UniProtKB
Biological Process positive regulation of protein export from nucleusIEA:Ensembl
Biological Process protein localizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of cyclin-dependent protein serine/threonine kinase activityIEA:Ensembl
Biological Process regulation of epidermal cell divisionISS:UniProtKB
Biological Process release of cytochrome c from mitochondriaManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process stem cell proliferationIEA:Ensembl
Cellular Location
Cytoplasm
Nucleus
Secreted
May be secreted by a non-classical secretory pathway.
PTM
Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation.
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Anti-SFN antibodies

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Mouse Anti-SFN Recombinant Antibody (CBXS-3721) (CBMAB-S0996-CQ)

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Target: SFN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-3721
Application*: IF, IP
Datasheet SDS

Mouse Anti-SFN Recombinant Antibody (SPM159) (CBMAB-1212-LY)

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Target: SFN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: SPM159
Application*: P
Datasheet SDS

Mouse Anti-SFN Recombinant Antibody (2G2) (CBMAB-A8028-LY)

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Target: SFN
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2G2
Application*: WB, E
Datasheet SDS

Mouse Anti-SFN Recombinant Antibody (1E7) (CBMAB-A8027-LY)

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Target: SFN
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1E7
Application*: WB, E
Datasheet SDS

Mouse Anti-SFN Recombinant Antibody (1E6) (CBMAB-A8026-LY)

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Target: SFN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1E6
Application*: WB, E
Datasheet SDS

Mouse Anti-SFN Recombinant Antibody (CBXS-0304) (CBMAB-S3279-CQ)

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Target: SFN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-0304
Application*: P, WB
Datasheet SDS

Mouse Anti-SFN Recombinant Antibody (CBXS-0303) (CBMAB-S3278-CQ)

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Target: SFN
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-0303
Application*: IF, SE, E, WB
Datasheet SDS

Mouse Anti-SFN Recombinant Antibody (CBXS-0302) (CBMAB-S3277-CQ)

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Target: SFN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-0302
Application*: WB, P
Datasheet SDS

Mouse Anti-SFN Recombinant Antibody (CBXS-0301) (CBMAB-S3276-CQ)

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Target: SFN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-0301
Application*: IF, P, IP, WB
Datasheet SDS

Mouse Anti-SFN Recombinant Antibody (CBXS-0300) (CBMAB-S3275-CQ)

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Target: SFN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-0300
Application*: IP, WB
Datasheet SDS

Mouse Anti-SFN (AA 1-249) Recombinant Antibody (CBXS-0299) (CBMAB-S3274-CQ)

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Target: SFN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0299
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-SFN Recombinant Antibody (CBXS-4801) (CBMAB-S2027-CQ)

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Target: SFN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-4801
Application*: P, WB
Datasheet SDS

Mouse Anti-SFN Recombinant Antibody (CBXS-5606) (CBMAB-S0484-CQ)

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Target: SFN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5606
Application*: E, IF, IH, WB
Datasheet SDS

Mouse Anti-SFN Recombinant Antibody (CBLY2-108) (CBMAB-1214-LY)

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Target: SFN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLY2-108
Application*: F
Datasheet SDS

Mouse Anti-SFN Recombinant Antibody (CBLY2-107) (CBMAB-1213-LY)

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Target: SFN
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLY2-107
Application*: WB, E
Datasheet SDS

Mouse Anti-SFN Recombinant Antibody (CS112-2A8) (CBMAB-1211-LY)

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Target: SFN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CS112-2A8
Application*: WB, IP
Datasheet SDS

Mouse Anti-SFN Recombinant Antibody (3C3) (CBMAB-1210-LY)

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Target: SFN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3C3
Application*: WB, P
Datasheet SDS

Mouse Anti-SFN Recombinant Antibody (1.T.28) (CBMAB-1208-LY)

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Target: SFN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Pig
Clone: 1.T.28
Application*: WB, IH
Datasheet SDS

Mouse Anti-SFN Antibody (11BA29) (CBMAB-1560CQ)

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Target: SFN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11BA29
Application*: E, IH, M, WB
Datasheet SDS

Mouse Anti-SFN Antibody (11BA28) (CBMAB-1559CQ)

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Target: SFN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11BA28
Application*: E, P, IH, M, WB
Datasheet SDS

Mouse Anti-SFN Antibody (11BA27) (CBMAB-1558CQ)

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Target: SFN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11BA27
Application*: E, WB
Datasheet SDS

Rabbit Anti-SFN Recombinant Antibody (BA0296) (CBMAB-0823CQ)

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Target: SFN
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: BA0296
Application*: P, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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