Human Recombinant SFN protein (V2LY-0526-LY1829)

Name: Human Recombinant SFN protein
SKU: V2LY-0526-LY1829
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Expressed Host

E. coli

Protein Species

Human

Protein Construction

This product is Human Recombinant SFN protein consist of Amino Acid: 1-248 and predicts a molecular mass of 28 kDa.

Molecule Mass

28 kDa

Sequence

Amino Acid: 1-248

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>97% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, Glycerol, PMSF

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

SFN

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
p53-regulated inhibitor of G2/M progression.

Biological Process

Biological Process establishment of skin barrierISS:UniProtKB
Biological Process intrinsic apoptotic signaling pathway in response to DNA damageManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process keratinizationIEA:Ensembl
Biological Process keratinocyte developmentIEA:Ensembl
Biological Process keratinocyte proliferationIEA:Ensembl
Biological Process negative regulation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process negative regulation of keratinocyte proliferationIEA:Ensembl
Biological Process negative regulation of protein kinase activityManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of stem cell proliferationIEA:Ensembl
Biological Process positive regulation of cell growthIEA:Ensembl
Biological Process positive regulation of epidermal cell differentiationISS:UniProtKB
Biological Process positive regulation of protein export from nucleusIEA:Ensembl
Biological Process protein localizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of cyclin-dependent protein serine/threonine kinase activityIEA:Ensembl
Biological Process regulation of epidermal cell divisionISS:UniProtKB
Biological Process release of cytochrome c from mitochondriaManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process stem cell proliferationIEA:Ensembl

Cellular Location

Cytoplasm
Nucleus
Secreted
May be secreted by a non-classical secretory pathway.

PTM

Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant SFN protein-1 (CAT#: V2LY-0526-LY1830)

Human Recombinant SFN protein, GST Tag (CAT#: V2LY-0526-LY1831)

Human Recombinant SFN protein, His Tag (CAT#: V2LY-0526-LY1832)

Human Recombinant SFN protein, GST Tag-1 (CAT#: V2LY-0526-LY1833)

Mouse Recombinant SFN protein (CAT#: V2LY-0526-LY7747)

Related Products

Human Recombinant SFN protein, His Tag (CAT#: V2LY-0526-LY1832)

Mouse Anti-SFN Recombinant Antibody (1.T.28) (CAT#: CBMAB-1208-LY)

Mouse Anti-SFN Recombinant Antibody (1E6) (CAT#: CBMAB-A8026-LY)

Mouse Anti-SFN Recombinant Antibody (CBXS-0300) (CAT#: CBMAB-S3275-CQ)

Mouse Anti-SFN Recombinant Antibody (CBXS-4801) (CAT#: CBMAB-S2027-CQ)

Human Recombinant SFN protein, GST Tag (CAT#: V2LY-0526-LY1831)

Mouse Anti-SFN Recombinant Antibody (SPM159) (CAT#: CBMAB-1212-LY)

Mouse Anti-SFN Antibody (11BA29) (CAT#: CBMAB-1560CQ)

Mouse Anti-SFN Recombinant Antibody (CBXS-0301) (CAT#: CBMAB-S3276-CQ)

Mouse Recombinant SFN protein (CAT#: V2LY-0526-LY7747)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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