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Rabbit Anti-SFN Recombinant Antibody (BA0296) (CBMAB-0823CQ)

This product is a rabbit antibody that recognizes SFN. The antibody BA0296 can be used for immunoassay techniques such as: IHC-P, WB.
See all SFN antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Rat
Clone
BA0296
Antibody Isotype
IgG
Application
IHC-P, WB

Basic Information

Immunogen
Human 14-3-3 sigma aa 50-150
Specificity
Human, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SFN
Introduction
This gene encodes a cell cycle checkpoint protein.Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
Entrez Gene ID
Human2810
Rat313017
UniProt ID
HumanP31947
RatG3V9A3
Alternative Names
YWHAS
Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
p53-regulated inhibitor of G2/M progression.
Biological Process
Biological Process establishment of skin barrierISS:UniProtKB
Biological Process intrinsic apoptotic signaling pathway in response to DNA damageManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process keratinizationIEA:Ensembl
Biological Process keratinocyte developmentIEA:Ensembl
Biological Process keratinocyte proliferationIEA:Ensembl
Biological Process negative regulation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process negative regulation of keratinocyte proliferationIEA:Ensembl
Biological Process negative regulation of protein kinase activityManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of stem cell proliferationIEA:Ensembl
Biological Process positive regulation of cell growthIEA:Ensembl
Biological Process positive regulation of epidermal cell differentiationISS:UniProtKB
Biological Process positive regulation of protein export from nucleusIEA:Ensembl
Biological Process protein localizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of cyclin-dependent protein serine/threonine kinase activityIEA:Ensembl
Biological Process regulation of epidermal cell divisionISS:UniProtKB
Biological Process release of cytochrome c from mitochondriaManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process stem cell proliferationIEA:Ensembl
Cellular Location
Cytoplasm
Nucleus
Secreted
May be secreted by a non-classical secretory pathway.
PTM
Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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