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Mouse Anti-SFXN1 Recombinant Antibody (CBYJT-1672) (CBMAB-T0721-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1672
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
Purified C5b-9.Immunogen type: Purified protein
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sideroflexin 1
Introduction
SFXN1 (Sideroflexin 1) is a Protein Coding gene. Diseases related to SFXN1 include Aceruloplasminemia. Gene Ontology (GO) annotations related to SFXN1 include cation transmembrane transporter activity and ion transmembrane transporter activity. An important paralog of SFXN1 is SFXN3.
Entrez Gene ID
94081
UniProt ID
Q9H9B4
Alternative Names
Sideroflexin 1; Tricarboxylate Carrier Protein; TCC; Sideroflexin-1; SLC56A1
Function
Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778).
May also transport other amino acids including alanine and cysteine (PubMed:30442778).
Biological Process
Biological Process erythrocyte differentiationIEA:Ensembl
Biological Process iron ion transportIEA:Ensembl
Biological Process L-alanine transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process L-serine transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process mitochondrial transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process one-carbon metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process serine import into mitochondrionManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Mitochondrion inner membrane
Topology
Mitochondrial matrix: 2-102
Helical: 103-120
Mitochondrial intermembrane: 121-146
Helical: 147-167
Mitochondrial matrix: 168-174
Helical: 175-195
Mitochondrial intermembrane: 196-228
Helical: 229-249
Mitochondrial matrix: 250-266
Helical: 267-287
Mitochondrial intermembrane: 288-322
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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