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Mouse Anti-SFXN1 Recombinant Antibody (CBYJT-1673) (CBMAB-T0722-YJ)


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Summary

Host Animal
Mouse
Specificity
Human, Horse, Pig
Clone
CBYJT-1673
Antibody Isotype
IgG2a
Application
FuncS, Immunoassay, IF, IHC-P

Basic Information

Specificity
Human, Horse, Pig
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, 0.1% BSA
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sideroflexin 1
Introduction
SFXN1 has several functions. Might be involved in the transport of a component required for iron utilization into or out of the mitochondria. erythrocyte differentiation, iron ion transport.
Entrez Gene ID
Human94081
Horse100069168
Pig100049699
UniProt ID
HumanQ9H9B4
HorseF7A7G2
PigA5A761
Alternative Names
TCC; SLC56A1
Function
Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778).
May also transport other amino acids including alanine and cysteine (PubMed:30442778).
Biological Process
Biological Process erythrocyte differentiationIEA:Ensembl
Biological Process iron ion transportIEA:Ensembl
Biological Process L-alanine transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process L-serine transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process mitochondrial transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process one-carbon metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process serine import into mitochondrionManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Mitochondrion inner membrane
Topology
Mitochondrial matrix: 2-102
Helical: 103-120
Mitochondrial intermembrane: 121-146
Helical: 147-167
Mitochondrial matrix: 168-174
Helical: 175-195
Mitochondrial intermembrane: 196-228
Helical: 229-249
Mitochondrial matrix: 250-266
Helical: 267-287
Mitochondrial intermembrane: 288-322
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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