Mouse Anti-SGCA Recombinant Antibody (CBXS-4805) (CBMAB-S2031-CQ)

Name: Mouse Anti-SGCA Recombinant Antibody (CBXS-4805)
SKU: CBMAB-S2031-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-4805

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SGCA

Introduction

This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

6442

UniProt ID

Q16586

Alternative Names

Sarcoglycan Alpha; Adhalin; Sarcoglycan, Alpha (50kDa Dystrophin-Associated Glycoprotein); 50 KDa Dystrophin-Associated Glycoprotein; Limb Girdle Muscular Dystrophy 2D; Dystroglycan-2; 50kD DAG; Alpha-SG;

Function

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

Biological Process

Biological Process muscle contractionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process muscle organ developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process response to denervation involved in regulation of muscle adaptationIEA:Ensembl
Biological Process skeletal muscle tissue regenerationIEA:Ensembl

Cellular Location

Cell membrane, sarcolemma
Cytoplasm, cytoskeleton

Involvement in disease

Muscular dystrophy, limb-girdle, autosomal recessive 3 (LGMDR3):
An autosomal recessive degenerative myopathy characterized by progressive muscle wasting from early childhood with loss of independent ambulation by teenage years. Muscle biopsy shows necrosis, decreased immunostaining for alpha sarcoglycan, and adhalin deficiency.

Topology

Extracellular: 24-290
Helical: 291-311
Cytoplasmic: 312-387

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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