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Mouse Anti-SGCA Antibody (IVD3(1)A9) (CBMAB-1561CQ)

This product is a mouse antibody that recognizes SGCA. The antibody IVD3(1)A9 can be used for immunoassay techniques such as: IF, IHC, IP, WB.
See all SGCA antibodies

Summary

Host Animal
Mouse
Specificity
Rabbit, Dog, Human, Mouse, Rat, Sheep
Clone
IVD3(1)A9
Antibody Isotype
IgG1, κ
Application
IF, IHC, IP, WB

Basic Information

Immunogen
Isolated membranes from skeletal muscle
Specificity
Rabbit, Dog, Human, Mouse, Rat, Sheep
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SGCA
Introduction
This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Diseases associated with SGCA include Muscular Dystrophy, Limb-Girdle, Type 2D and Limb-Girdle Muscular Dystrophy. Among its related pathways are Arrhythmogenic right ventricular cardiomyopathy (ARVC) and Dilated cardiomyopathy (DCM).
Entrez Gene ID
Human6442
Mouse20391
Rat303468
Sheep101108143
Dog609265
Rabbit100009178
UniProt ID
HumanQ16586
MouseP82350
RatD3ZDQ9
SheepW5P4U7
DogQ8SQ72
RabbitQ28686
Alternative Names
ADL; DAG2; 50DAG; DMDA2; LGMD2D; SCARMD1; adhalin
Function
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Biological Process
Biological Process muscle contractionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process muscle organ developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process response to denervation involved in regulation of muscle adaptationIEA:Ensembl
Biological Process skeletal muscle tissue regenerationIEA:Ensembl
Cellular Location
Cell membrane, sarcolemma
Cytoplasm, cytoskeleton
Involvement in disease
Muscular dystrophy, limb-girdle, autosomal recessive 3 (LGMDR3):
An autosomal recessive degenerative myopathy characterized by progressive muscle wasting from early childhood with loss of independent ambulation by teenage years. Muscle biopsy shows necrosis, decreased immunostaining for alpha sarcoglycan, and adhalin deficiency.
Topology
Extracellular: 24-290
Helical: 291-311
Cytoplasmic: 312-387
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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