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Mouse Anti-SHANK3 Recombinant Antibody (N69/46) (CBMAB-0828CQ)

This product is a mouse antibody that recognizes SHANK3. The antibody N69/46 can be used for immunoassay techniques such as: IF, WB.
See all SHANK3 antibodies

Summary

Host Animal
Mouse
Specificity
Rat, Mouse, Human
Clone
N69/46
Antibody Isotype
IgG2b
Application
IF, WB

Basic Information

Immunogen
Synthetic peptide from Rat SHANK3 aa 800-900
Specificity
Rat, Mouse, Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SH3 And Multiple Ankyrin Repeat Domains 3
Introduction
This gene is a member of the Shank gene family. Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters.
Entrez Gene ID
Human85358
Mouse58234
Rat59312
UniProt ID
HumanQ9BYB0
MouseQ4ACU6
RatQ9JLU4
Alternative Names
PSAP2; SCZD15; PROSAP2; SPANK-2; DEL22q13.3
Function
Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.
Biological Process
Biological Process adult behaviorManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process AMPA glutamate receptor clusteringBy SimilarityISS:BHF-UCL
Biological Process brain morphogenesisISS:BHF-UCL
Biological Process dendritic spine morphogenesisISS:BHF-UCL
Biological Process guanylate kinase-associated protein clusteringISS:BHF-UCL
Biological Process learningManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process MAPK cascadeISS:BHF-UCL
Biological Process memoryISS:BHF-UCL
Biological Process negative regulation of actin filament bundle assemblyISS:BHF-UCL
Biological Process negative regulation of cell volumeISS:BHF-UCL
Biological Process NMDA glutamate receptor clusteringISS:BHF-UCL
Biological Process positive regulation of AMPA receptor activityISS:BHF-UCL
Biological Process positive regulation of dendritic spine developmentBy SimilarityISS:BHF-UCL
Biological Process positive regulation of excitatory postsynaptic potentialBy SimilarityISS:BHF-UCL
Biological Process positive regulation of glutamate receptor signaling pathwayBy SimilarityISS:BHF-UCL
Biological Process positive regulation of long-term neuronal synaptic plasticityISS:BHF-UCL
Biological Process positive regulation of long-term synaptic potentiationISS:BHF-UCL
Biological Process positive regulation of synapse structural plasticityISS:BHF-UCL
Biological Process positive regulation of synaptic transmission, glutamatergicBy SimilarityISS:BHF-UCL
Biological Process postsynaptic density assemblyISS:BHF-UCL
Biological Process regulation of dendritic spine morphogenesisBy SimilarityISS:BHF-UCL
Biological Process regulation of long-term synaptic depressionBy SimilarityISS:BHF-UCL
Biological Process regulation of long-term synaptic potentiationISS:BHF-UCL
Biological Process social behaviorManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process striatal medium spiny neuron differentiationISS:BHF-UCL
Biological Process synapse assemblyISS:BHF-UCL
Biological Process vocal learningManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process vocalization behaviorManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular Location
Cytoplasm
Postsynaptic density
Cell projection, dendritic spine
In neuronal cells, extends into the region subjacent to the postsynaptic density (PSD).
Involvement in disease
Phelan-McDermid syndrome (PHMDS):
A developmental disorder with variable features. Common features include neonatal hypotonia, global developmental delay, normal to accelerated growth, absent to severely delayed speech, autistic behavior, and minor dysmorphic features.
Schizophrenia 15 (SCZD15):
A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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