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Mouse Anti-SHISA5 Recombinant Antibody (CBXS-4917) (CBMAB-S2139-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4917
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
SHISA5 (AAH01463, 1 a.a.-137 a.a) Full length recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
shisa homolog 5 (Xenopus laevis)
Introduction
This gene encodes a member of the shisa family. The encoded protein is localized to the endoplasmic reticulum, and together with p53 induces apoptosis in a caspase-dependent manner. Alternative splicing results in multiple transcript variants. Related pseudogenes of this gene are found on chromosome X.
Entrez Gene ID
51246
UniProt ID
Q8N114
Alternative Names
Shisa Family Member 5; Putative NF-Kappa-B-Activating Protein 120; SCOTIN; Shisa Homolog 5 (Xenopus Laevis); Protein Shisa-5; Shisa Homolog 5;
Function
Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis.
Biological Process
Biological Process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorIEA:Ensembl
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentHMP:UniProtKB
Cellular Location
Endoplasmic reticulum membrane
Nucleus membrane
Topology
Extracellular: 29-105
Helical: 106-126
Cytoplasmic: 127-240
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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