Mouse Anti-SIAE Recombinant Antibody (CBXS-1114) (CBMAB-S4000-CQ)

Name: Mouse Anti-SIAE Recombinant Antibody (CBXS-1114)
SKU: CBMAB-S4000-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-1114

Application

IHC-P

Immunogen

Recombinant Human sialate O-acetylesterase Protein

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Sialic Acid Acetylesterase

Introduction

This gene encodes an enzyme which removes 9-O-acetylation modifications from sialic acids. Mutations in this gene are associated with susceptibility to autoimmune disease 6. Multiple transcript variants encoding different isoforms, found either in the cytosol or in the lysosome, have been found for this gene.

Entrez Gene ID

54414

UniProt ID

Q9HAT2

Alternative Names

Sialic Acid Acetylesterase; Sialic Acid-Specific Acetylesterase II; EC 3.1.1.53; H-Lse; YSG2; Cytosolic Sialic Acid 9-O-Acetylesterase Homolog; Sialic Acid-Specific 9-O-Acetylesterase;

Function

Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid.

Biological Process

Biological Process carbohydrate metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of immune system processManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Lysosome
Secreted

Involvement in disease

Autoimmune disease 6 (AIS6):
Individuals manifesting susceptibility to autoimmune disease type 6 can suffer from juvenile idiopathic arthritis, rheumatoid arthritis, multiple sclerosis, Sjogren syndrome, systemic lupus erythematosus, type 1 diabetes, ulcerative colitis, and Crohn disease.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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