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Mouse Anti-SIAE Recombinant Antibody (CBXS-1114) (CBMAB-S4000-CQ)

This product is a mouse antibody that recognizes SIAE. The antibody CBXS-1114 can be used for immunoassay techniques such as: IHC-P.
See all SIAE antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-1114
Antibody Isotype
IgG
Application
IHC-P

Basic Information

Immunogen
Recombinant Human sialate O-acetylesterase Protein
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sialic Acid Acetylesterase
Introduction
This gene encodes an enzyme which removes 9-O-acetylation modifications from sialic acids. Mutations in this gene are associated with susceptibility to autoimmune disease 6. Multiple transcript variants encoding different isoforms, found either in the cytosol or in the lysosome, have been found for this gene.
Entrez Gene ID
54414
UniProt ID
Q9HAT2
Alternative Names
Sialic Acid Acetylesterase; Sialic Acid-Specific Acetylesterase II; EC 3.1.1.53; H-Lse; YSG2; Cytosolic Sialic Acid 9-O-Acetylesterase Homolog; Sialic Acid-Specific 9-O-Acetylesterase;
Function
Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid.
Biological Process
Biological Process carbohydrate metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of immune system processManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Lysosome
Secreted
Involvement in disease
Autoimmune disease 6 (AIS6):
Individuals manifesting susceptibility to autoimmune disease type 6 can suffer from juvenile idiopathic arthritis, rheumatoid arthritis, multiple sclerosis, Sjogren syndrome, systemic lupus erythematosus, type 1 diabetes, ulcerative colitis, and Crohn disease.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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