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Rabbit Anti-SIGLEC11 Recombinant Antibody (CBXS-1606) (CBMAB-S4455-CQ)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXS-1606
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sialic Acid Binding Ig Like Lectin 11
Introduction
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
114132
UniProt ID
Q96RL6
Alternative Names
Sialic Acid Binding Ig Like Lectin 11; Siglec-11; Sialic Acid Binding Ig-Like Lectin 11; Sialic Acid-Binding Ig-Like Lectin 11; Sialic Acid-Binding Lectin 11;
Function
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
Biological Process
Cell adhesion
Cellular Location
Membrane
Topology
Extracellular: 28-561
Helical: 562-584
Cytoplasmic: 585-698
PTM
Phosphorylated on tyrosine residues.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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