Mouse Anti-SIGLEC11 Recombinant Antibody (CBXS-1895) (CBMAB-S0133-CQ)

Name: Mouse Anti-SIGLEC11 Recombinant Antibody (CBXS-1895)
SKU: CBMAB-S0133-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-1895

Application

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Sialic Acid Binding Ig Like Lectin 11

Introduction

This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

114132

UniProt ID

Q96RL6

Alternative Names

Sialic Acid Binding Ig Like Lectin 11; Siglec-11; Sialic Acid Binding Ig-Like Lectin 11; Sialic Acid-Binding Ig-Like Lectin 11; Sialic Acid-Binding Lectin 11;

Function

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

Biological Process

Cell adhesion

Cellular Location

Membrane

Topology

Extracellular: 28-561
Helical: 562-584
Cytoplasmic: 585-698

PTM

Phosphorylated on tyrosine residues.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Rabbit Anti-SIGLEC11 Recombinant Antibody (CBXS-1606) (CAT#: CBMAB-S4455-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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