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Mouse Anti-SIGLEC5 Recombinant Antibody (1A5) (CBMAB-C0468-LY)

This product is antibody recognizes SIGLEC5. The antibody 1A5 immunoassay techniques such as: FC.
See all SIGLEC5 antibodies
Published Data
Fig.1 Localization and expression of the siglec-5 gene.
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Fig.2 Western blot analyses of neutrophil lysates with anti–siglec-5 antiserum.
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Fig.3 Anti-Siglec-5 Abs stain chimpanzee T and B cells.
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Fig.4 Tissue expression pattern of hSiglec-5 using monoclonal antibody 1A5.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
1A5
Antibody Isotype
IgG1, κ
Application
FC

Basic Information

Immunogen
Extracellular region of Siglec-5
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.2% (w/v) BSA
Preservative
0.09% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Sialic Acid Binding Ig Like Lectin 5
Introduction
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012]
Entrez Gene ID
8778
UniProt ID
O15389
Alternative Names
Sialic Acid Binding Ig Like Lectin 5; Obesity-Binding Protein 2; OB-Binding Protein 2; CD33 Antigen-Like 2; SIGLEC-5; CD33L2; OB-BP2;
Function
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Biological Process
Cell adhesion
Cellular Location
Membrane
Topology
Extracellular: 17-441
Helical: 442-462
Cytoplasmic: 463-551
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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