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SIGLEC5

SIGLEC5 is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.
Full Name
Sialic Acid Binding Ig Like Lectin 5
Function
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Biological Process
Cell adhesion
Cellular Location
Membrane
Topology
Extracellular: 17-441
Helical: 442-462
Cytoplasmic: 463-551

Anti-SIGLEC5 antibodies

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Target: SIGLEC5
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 1RNM44N
Application*: F, IC, IF, C
Target: SIGLEC5
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBXS-2579
Application*: IH, WB
Target: SIGLEC5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-1689
Application*: WB, IH
Target: SIGLEC5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1688
Application*: ED
Target: SIGLEC5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1142
Application*: E
Target: SIGLEC5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5242
Application*: F
Target: SIGLEC5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5085
Application*: WB, IH, P
Target: SIGLEC5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3813
Application*: WB, IP, E, C, N, F, IF
Target: SIGLEC5
Host: Mouse
Specificity: Human
Clone: CBXS-3636
Application*: EC
Target: SIGLEC5
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBXS-5813
Application*: IH, WB
Target: SIGLEC5
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3560
Application*: F
Target: SIGLEC5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1690
Application*: F
Target: SIGLEC5
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYY-C0700
Application*: F, IP
Target: SIGLEC5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1A5
Application*: F
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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