SIGLEC5

SIGLEC5 is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.
Full Name
Sialic Acid Binding Ig Like Lectin 5
Function
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Biological Process
Cell adhesion
Cellular Location
Membrane
Topology
Extracellular: 17-441
Helical: 442-462
Cytoplasmic: 463-551
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Anti-SIGLEC5 antibodies

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Rat Anti-SIGLEC5 Recombinant Antibody (1RNM44N) (CBMAB-C0557-LY)

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Target: SIGLEC5
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 1RNM44N
Application*: F, IC, IF, C
Datasheet SDS

Mouse Anti-SIGLEC5 Recombinant Antibody (CBT4028) (V2LY-0625-LY1149)

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Target: SIGLEC5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT4028
Application*: F
Datasheet SDS

Mouse Anti-SIGLEC5 Recombinant Antibody (CBXS-2579) (CBMAB-S5335-CQ)

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Target: SIGLEC5
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBXS-2579
Application*: IH, WB
Datasheet SDS

Mouse Anti-SIGLEC5 Recombinant Antibody (CBXS-1689) (CBMAB-S4529-CQ)

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Target: SIGLEC5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-1689
Application*: WB, IH
Datasheet SDS

Mouse Anti-SIGLEC5 Recombinant Antibody (CBXS-1688) (CBMAB-S4528-CQ)

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Target: SIGLEC5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1688
Application*: ED
Datasheet SDS

Mouse Anti-SIGLEC5 Recombinant Antibody (CBXS-1142) (CBMAB-S4025-CQ)

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Target: SIGLEC5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1142
Application*: E
Datasheet SDS

Mouse Anti-SIGLEC5 Recombinant Antibody (CBXS-5242) (CBMAB-S2457-CQ)

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Target: SIGLEC5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5242
Application*: F
Datasheet SDS

Mouse Anti-SIGLEC5 Recombinant Antibody (CBXS-5085) (CBMAB-S2305-CQ)

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Target: SIGLEC5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5085
Application*: WB, IH, P
Datasheet SDS

Mouse Anti-SIGLEC5 Recombinant Antibody (CBXS-3813) (CBMAB-S1084-CQ)

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Target: SIGLEC5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3813
Application*: WB, IP, E, C, N, F, IF
Datasheet SDS

Mouse Anti-SIGLEC5 Recombinant Antibody (CBXS-3636) (CBMAB-S0918-CQ)

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Target: SIGLEC5
Host: Mouse
Specificity: Human
Clone: CBXS-3636
Application*: EC
Datasheet SDS

Mouse Anti-SIGLEC5 Recombinant Antibody (CBXS-5813) (CBMAB-S0669-CQ)

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Target: SIGLEC5
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBXS-5813
Application*: IH, WB
Datasheet SDS

Human Anti-SIGLEC5 Recombinant Antibody (CBXS-3560) (CBMAB-S0394-CQ)

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Target: SIGLEC5
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3560
Application*: F
Datasheet SDS

Mouse Anti-SIGLEC5 Recombinant Antibody (CBXS-1690) (CBMAB-S0098-CQ)

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Target: SIGLEC5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1690
Application*: F
Datasheet SDS

Rat Anti-SIGLEC5 Recombinant Antibody (CBYY-C0700) (CBMAB-C2067-YY)

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Target: SIGLEC5
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYY-C0700
Application*: F, IP
Datasheet SDS

Mouse Anti-SIGLEC5 Recombinant Antibody (1A5) (CBMAB-C0468-LY)

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Target: SIGLEC5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1A5
Application*: F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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