Rabbit Anti-SIK2 Recombinant Antibody (D28G3) (CBMAB-CP2437-LY)

Name: Rabbit Anti-SIK2 Recombinant Antibody (D28G3)
SKU: CBMAB-CP2437-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Rabbit

Clone

D28G3

Application

WB, IP

Immunogen

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human SIK2 protein.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

100 µg/ml BSA, 50% glycerol

Preservative

0.02% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Salt Inducible Kinase 2

Entrez Gene ID

Human	23235
Mouse	235344
Rat	315649

UniProt ID

Human	Q9H0K1
Mouse	Q8CFH6
Rat	E9PSK5

Alternative Names

Salt Inducible Kinase 2; Serine/Threonine-Protein Kinase SNF1-Like Kinase 2; SNF1-Like Kinase 2; Qin-Induced Kinase; EC 2.7.11.1; SNF1LK2; SIK-2; QIK;

Function

Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:23322770, PubMed:26983400).
Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (PubMed:15454081).
Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity (PubMed:21084751, PubMed:26983400).
In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL (PubMed:21084751, PubMed:26983400).
Also plays a role in thymic T-cell development (By similarity).

Biological Process

Biological Process cellular response to glucose starvationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process intracellular signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of insulin receptor signaling pathwayISS:UniProtKB

Cellular Location

Cytoplasm
Endoplasmic reticulum membrane

PTM

Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39 (PubMed:14976552).
Phosphorylated at Thr-484 in response to insulin in adipocytes (PubMed:30586628).
Acetylation at Lys-53 inhibits kinase activity. Deacetylated by HDAC6.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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