SIK2

SIK2 plays critical roles in neuronal survival, is modulated by CaMK I/IV, and regulates CREB via TORC1.
Full Name
Salt Inducible Kinase 2
Function
Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:23322770, PubMed:26983400).
Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (PubMed:15454081).
Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity (PubMed:21084751, PubMed:26983400).
In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL (PubMed:21084751, PubMed:26983400).
Also plays a role in thymic T-cell development (By similarity).
Biological Process
Biological Process cellular response to glucose starvationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process intracellular signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of insulin receptor signaling pathwayISS:UniProtKB
Cellular Location
Cytoplasm
Endoplasmic reticulum membrane
PTM
Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39 (PubMed:14976552).
Phosphorylated at Thr-484 in response to insulin in adipocytes (PubMed:30586628).
Acetylation at Lys-53 inhibits kinase activity. Deacetylated by HDAC6.
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Anti-SIK2 antibodies

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Rabbit Anti-SIK2 Recombinant Antibody (D28G3) (CBMAB-CP2437-LY)

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Target: SIK2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D28G3
Application*: WB, IP
Datasheet SDS

Mouse Anti-SIK2 Recombinant Antibody (4H6) (CBMAB-A8129-LY)

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Target: SIK2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4H6
Application*: WB, E
Datasheet SDS

Mouse Anti-SIK2 Recombinant Antibody (4C6) (CBMAB-A8128-LY)

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Target: SIK2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4C6
Application*: WB, E
Datasheet SDS

Mouse Anti-SIK2 Recombinant Antibody (S15G10) (CBMAB-S6512-CQ)

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Target: SIK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: S15G10
Application*: WB, IP, P, IF
Datasheet SDS

Mouse Anti-SIK2 Recombinant Antibody (CBXS-3263) (CBMAB-S6004-CQ)

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Target: SIK2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-3263
Application*: E, WB
Datasheet SDS

Mouse Anti-SIK2 Recombinant Antibody (CBXS-0375) (CBMAB-S3337-CQ)

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Target: SIK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0375
Application*: IF, P, IP, WB
Datasheet SDS

Rabbit Anti-SIK2 Recombinant Antibody (CBXS-5366) (CBMAB-S2579-CQ)

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Target: SIK2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXS-5366
Application*: WB, IP
Datasheet SDS

Mouse Anti-SIK2 Recombinant Antibody (CBXS-5004) (CBMAB-S2226-CQ)

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Target: SIK2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-5004
Application*: E, IC, IF, WB
Datasheet SDS

Mouse Anti-SIK2 Recombinant Antibody (CBXS-3996) (CBMAB-S1257-CQ)

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Target: SIK2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-3996
Application*: IF, IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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