Rabbit Anti-SIRT3 Recombinant Antibody (CBXS-3432) (CBMAB-S6163-CQ)

Name: Rabbit Anti-SIRT3 Recombinant Antibody (CBXS-3432)
SKU: CBMAB-S6163-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

CBXS-3432

Application

ELISA, IHC, IP, WB

Immunogen

Synthetic peptide derived from the sequence of human SIRT 3 protein (KLH)

Specificity

Human, Monkey, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

10 mM sodium HEPES, pH 7.5, 150 mM sodium chloride, 0.1 mg/mL BSA, 50% glycerol

Preservative

0.02% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SIRT3

Introduction

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.

Entrez Gene ID

Human	23410
Monkey	720737
Rat	293615

UniProt ID

Human	Q9NTG7
Rat	B2RZ31

Alternative Names

Sirtuin 3; Regulatory Protein SIR2 Homolog 3; SIR2-Like Protein 3; SIR2L3; Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 3 (S. Cerevisiae); Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog) 3; Mitochondrial Nicotinamide Adenine Dinucleotide-Dependent Deacetylase; Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog 3;

Function

NAD-dependent protein deacetylase (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090, PubMed:19535340).
Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090).
Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5PO (PubMed:16788062, PubMed:18680753, PubMed:24121500, PubMed:24252090, PubMed:19535340).
Contributes to the regulation of the cellular energy metabolism (PubMed:24252090).
Important for regulating tissue-specific ATP levels (PubMed:18794531).
In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301).
Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation (By similarity).

Biological Process

Biological Process aerobic respirationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process peptidyl-lysine deacetylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of catalase activityManual Assertion Based On ExperimentIDA:CACAO
Biological Process positive regulation of ceramide biosynthetic processISS:UniProtKB
Biological Process positive regulation of superoxide dismutase activityManual Assertion Based On ExperimentIDA:CACAO
Biological Process protein ADP-ribosylationBy SimilarityISS:GO_Central
Biological Process protein deacetylationManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Mitochondrion matrix

PTM

Processed by mitochondrial processing peptidase (MPP) to give a 28 kDa product. Such processing is probably essential for its enzymatic activity.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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