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Mouse Anti-SKIL Recombinant Antibody (1C12) (CBMAB-A8154-LY)

The product is antibody recognizes SKIL. The antibody 1C12 immunoassay techniques such as: WB, ELISA.
See all SKIL antibodies
Published Data
Fig.1 The in vitro translated GLI3 (WT) or p.M111T mutant and those that bound to SKIL were analyzed byWestern blotting and are indicated by a histogram in the right panel.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
1C12
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
SKIL (NP_005405.1, 236 a.a. ~ 313 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SKI-like oncogene
Entrez Gene ID
6498
UniProt ID
P12757
Alternative Names
SNO; SnoA; SnoN
Function
May have regulatory role in cell division or differentiation in response to extracellular signals.
Biological Process
Biological Process blastocyst formationIEA:Ensembl
Biological Process extrinsic apoptotic signaling pathway via death domain receptorsIEA:Ensembl
Biological Process intrinsic apoptotic signaling pathway in response to DNA damageIEA:Ensembl
Biological Process lens fiber cell differentiationIEA:Ensembl
Biological Process lymphocyte homeostasisIEA:Ensembl
Biological Process negative regulation of BMP signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of cell differentiationIEA:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of axonogenesisIMP:UniProtKB
Biological Process positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsIEA:Ensembl
Biological Process positive regulation of intrinsic apoptotic signaling pathway in response to DNA damageIEA:Ensembl
Biological Process regulation of cell cycleIEA:Ensembl
Biological Process response to antibioticIEP:UniProtKB
Biological Process response to cytokineIEA:Ensembl
Biological Process response to growth factorIDA:UniProtKB
Biological Process skeletal muscle tissue developmentIDA:UniProtKB
Biological Process spermatogenesisIEA:Ensembl
Biological Process transforming growth factor beta receptor signaling pathwayIEA:Ensembl
Cellular Location
acrosomal vesicle
cytoplasm
nucleoplasm
nucleus
PML body
protein-containing complex
transcription regulator complex
PTM
Ubiquitinated by RNF111 and RNF165, promoting proteasomal degradation, leading to enhance the BMP-Smad signaling.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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