SKIL

The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene.
Full Name
SKI-like oncogene
Function
May have regulatory role in cell division or differentiation in response to extracellular signals.
Biological Process
Biological Process blastocyst formationIEA:Ensembl
Biological Process extrinsic apoptotic signaling pathway via death domain receptorsIEA:Ensembl
Biological Process intrinsic apoptotic signaling pathway in response to DNA damageIEA:Ensembl
Biological Process lens fiber cell differentiationIEA:Ensembl
Biological Process lymphocyte homeostasisIEA:Ensembl
Biological Process negative regulation of BMP signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of cell differentiationIEA:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of axonogenesisIMP:UniProtKB
Biological Process positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsIEA:Ensembl
Biological Process positive regulation of intrinsic apoptotic signaling pathway in response to DNA damageIEA:Ensembl
Biological Process regulation of cell cycleIEA:Ensembl
Biological Process response to antibioticIEP:UniProtKB
Biological Process response to cytokineIEA:Ensembl
Biological Process response to growth factorIDA:UniProtKB
Biological Process skeletal muscle tissue developmentIDA:UniProtKB
Biological Process spermatogenesisIEA:Ensembl
Biological Process transforming growth factor beta receptor signaling pathwayIEA:Ensembl
Cellular Location
acrosomal vesicle
cytoplasm
nucleoplasm
nucleus
PML body
protein-containing complex
transcription regulator complex
PTM
Ubiquitinated by RNF111 and RNF165, promoting proteasomal degradation, leading to enhance the BMP-Smad signaling.
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Anti-SKIL antibodies

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Mouse Anti-SKIL Recombinant Antibody (1C12) (CBMAB-A8154-LY)

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Target: SKIL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1C12
Application*: WB, E
Datasheet SDS

Mouse Anti-SKIL Recombinant Antibody (CBXS-2292) (CBMAB-S5054-CQ)

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Target: SKIL
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBXS-2292
Application*: WB, IP, IF, P, E
Datasheet SDS

Mouse Anti-SKIL Recombinant Antibody (CBXS-2102) (CBMAB-S4867-CQ)

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Target: SKIL
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBXS-2102
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-SKIL Recombinant Antibody (CBXS-4905) (CBMAB-S2127-CQ)

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Target: SKIL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4905
Application*: WB, IH
Datasheet SDS

Mouse Anti-SKIL Recombinant Antibody (CBXS-4599) (CBMAB-S1839-CQ)

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Target: SKIL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4599
Application*: WB, P, IF
Datasheet SDS

Mouse Anti-SKIL Recombinant Antibody (CBXS-4467) (CBMAB-S1709-CQ)

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Target: SKIL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4467
Application*: P, WB
Datasheet SDS

Mouse Anti-SKIL Recombinant Antibody (CBXS-4211) (CBMAB-S1464-CQ)

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Target: SKIL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4211
Application*: WB
Datasheet SDS

Mouse Anti-SKIL Recombinant Antibody (CBXS-3906) (CBMAB-S1175-CQ)

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Target: SKIL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-3906
Application*: E, WB
Datasheet SDS

Mouse Anti-SKIL Recombinant Antibody (CBXS-3827) (CBMAB-S1097-CQ)

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Target: SKIL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3827
Application*: P, WB
Datasheet SDS

Mouse Anti-SKIL Monoclonal Antibody (1D1) (CBMAB-0110-LY)

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Target: SKIL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1D1
Application*: IP, M, WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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