Mouse Anti-SLA2 Recombinant Antibody (CBXS-5584) (CBMAB-S0200-CQ)

Name: Mouse Anti-SLA2 Recombinant Antibody (CBXS-5584)
SKU: CBMAB-S0200-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-5584

Application

WB, ELISA, IHC

Immunogen

Peptide Sequence-LRESLSFY

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Src Like Adaptor 2

Introduction

This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene.

Entrez Gene ID

84174

UniProt ID

Q9H6Q3

Alternative Names

Src Like Adaptor 2; Modulator Of Antigen Receptor Signaling; C20orf156; SLAP-2; SLAP2; MARS;

Function

Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.

Biological Process

Biological Process antigen receptor-mediated signaling pathwayManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process B cell mediated immunityManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process negative regulation of calcium-mediated signalingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of T cell receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of immune response1 PublicationNAS:UniProtKB
Biological Process T cell activationManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm
Isoform 1
Cell membrane
Cytoplasmic vesicle
Localized to the plasma membrane and intracellular vesicles, including late endosomal vesicles.
Isoform 2
Cytoplasm
May be cytoplasmic and is not localized to membranes.

PTM

Phosphorylated by CSF1R.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

SLA2 Matched Antibody Pair (1096) (CAT#: APMAB-1096LY)

SLA2 Matched Antibody Pair (1097) (CAT#: APMAB-1097LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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