SLA2
This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Full Name
Src Like Adaptor 2
Function
Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
Biological Process
Biological Process antigen receptor-mediated signaling pathwayManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process B cell mediated immunityManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process negative regulation of calcium-mediated signalingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of T cell receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of immune response1 PublicationNAS:UniProtKB
Biological Process T cell activationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process B cell mediated immunityManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process negative regulation of calcium-mediated signalingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of T cell receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of immune response1 PublicationNAS:UniProtKB
Biological Process T cell activationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Isoform 1
Cell membrane
Cytoplasmic vesicle
Localized to the plasma membrane and intracellular vesicles, including late endosomal vesicles.
Isoform 2
Cytoplasm
May be cytoplasmic and is not localized to membranes.
Isoform 1
Cell membrane
Cytoplasmic vesicle
Localized to the plasma membrane and intracellular vesicles, including late endosomal vesicles.
Isoform 2
Cytoplasm
May be cytoplasmic and is not localized to membranes.
PTM
Phosphorylated by CSF1R.
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Anti-SLA2 antibodies
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CompareTarget: SLA2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3G5
Application*: WB, E
Target: SLA2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: Z30P1F12
Application*: E, IH, WB
Target: SLA2
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBXS-2170
Application*: WB, IP, IF, E
Target: SLA2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1594
Application*: WB, IP, F, IF
Target: SLA2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4959
Application*: P, WB
Target: SLA2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4951
Application*: IF, WB
Target: SLA2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-4918
Application*: E, WB
Target: SLA2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4862
Application*: F, P, WB
Target: SLA2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4847
Application*: IF, WB
Target: SLA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4746
Application*: WB, F, IH
Target: SLA2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4624
Application*: F, IF, P, WB
Target: SLA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4603
Application*: F, WB
Target: SLA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4573
Application*: IF, WB
Target: SLA2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4385
Application*: P, WB
Target: SLA2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4075
Application*: F, P, WB
Target: SLA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4018
Application*: F, P, WB
Target: SLA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3975
Application*: F, WB
Target: SLA2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-5584
Application*: WB, E, IH
Target: SLA2
Specificity: Human
Target: SLA2
Specificity: Human
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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