SLA2

This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Full Name
Src Like Adaptor 2
Function
Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
Biological Process
Biological Process antigen receptor-mediated signaling pathwayManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process B cell mediated immunityManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process negative regulation of calcium-mediated signalingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of T cell receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of immune response1 PublicationNAS:UniProtKB
Biological Process T cell activationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Isoform 1
Cell membrane
Cytoplasmic vesicle
Localized to the plasma membrane and intracellular vesicles, including late endosomal vesicles.
Isoform 2
Cytoplasm
May be cytoplasmic and is not localized to membranes.
PTM
Phosphorylated by CSF1R.
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Anti-SLA2 antibodies

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Mouse Anti-SLA2 Recombinant Antibody (3G5) (CBMAB-A8158-LY)

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Target: SLA2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3G5
Application*: WB, E
Datasheet SDS

Recombinant Mouse Anti-SLA2 Recombinant Antibody (Z30P1F12) (CBMAB-XB1038-YC)

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Target: SLA2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: Z30P1F12
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-SLA2 Recombinant Antibody (CBXS-2170) (CBMAB-S4933-CQ)

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Target: SLA2
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBXS-2170
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-SLA2 Recombinant Antibody (CBXS-1594) (CBMAB-S4443-CQ)

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Target: SLA2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1594
Application*: WB, IP, F, IF
Datasheet SDS

Mouse Anti-SLA2 Recombinant Antibody (CBXS-4959) (CBMAB-S2181-CQ)

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Target: SLA2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4959
Application*: P, WB
Datasheet SDS

Mouse Anti-SLA2 Recombinant Antibody (CBXS-4951) (CBMAB-S2173-CQ)

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Target: SLA2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4951
Application*: IF, WB
Datasheet SDS

Mouse Anti-SLA2 Recombinant Antibody (CBXS-4918) (CBMAB-S2140-CQ)

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Target: SLA2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-4918
Application*: E, WB
Datasheet SDS

Mouse Anti-SLA2 Recombinant Antibody (CBXS-4862) (CBMAB-S2085-CQ)

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Target: SLA2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4862
Application*: F, P, WB
Datasheet SDS

Mouse Anti-SLA2 Recombinant Antibody (CBXS-4847) (CBMAB-S2071-CQ)

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Target: SLA2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4847
Application*: IF, WB
Datasheet SDS

Mouse Anti-SLA2 Recombinant Antibody (CBXS-4746) (CBMAB-S1975-CQ)

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Target: SLA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4746
Application*: WB, F, IH
Datasheet SDS

Mouse Anti-SLA2 Recombinant Antibody (CBXS-4624) (CBMAB-S1864-CQ)

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Target: SLA2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4624
Application*: F, IF, P, WB
Datasheet SDS

Mouse Anti-SLA2 Recombinant Antibody (CBXS-4603) (CBMAB-S1843-CQ)

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Target: SLA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4603
Application*: F, WB
Datasheet SDS

Mouse Anti-SLA2 Recombinant Antibody (CBXS-4573) (CBMAB-S1813-CQ)

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Target: SLA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4573
Application*: IF, WB
Datasheet SDS

Mouse Anti-SLA2 Recombinant Antibody (CBXS-4385) (CBMAB-S1628-CQ)

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Target: SLA2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4385
Application*: P, WB
Datasheet SDS

Mouse Anti-SLA2 Recombinant Antibody (CBXS-4075) (CBMAB-S1333-CQ)

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Target: SLA2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4075
Application*: F, P, WB
Datasheet SDS

Mouse Anti-SLA2 Recombinant Antibody (CBXS-4018) (CBMAB-S1279-CQ)

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Target: SLA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4018
Application*: F, P, WB
Datasheet SDS

Mouse Anti-SLA2 Recombinant Antibody (CBXS-3975) (CBMAB-S1238-CQ)

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Target: SLA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3975
Application*: F, WB
Datasheet SDS

Mouse Anti-SLA2 Recombinant Antibody (CBXS-5584) (CBMAB-S0200-CQ)

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Target: SLA2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-5584
Application*: WB, E, IH
Datasheet SDS

SLA2 Matched Antibody Pair (1097) (APMAB-1097LY)

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Target: SLA2
Specificity: Human
Datasheet SDS

SLA2 Matched Antibody Pair (1096) (APMAB-1096LY)

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Target: SLA2
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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