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Mouse Anti-SLAMF6 Recombinant Antibody (CBT3063) (V2LY-0625-LY1027)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3063
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Purified recombinant fragment of human CD352 (AA: extra 22-226) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SLAM Family Member 6
Entrez Gene ID
114836
Function
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (PubMed:11489943, PubMed:16920955).
Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A (PubMed:16920955).
In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (By similarity).
Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727, PubMed:16920955).
Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874).
In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response. In the absence of SH2D1A/SAP can transmit negative signals to CD4+ T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP. However, reported to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (By similarity).
Biological Process
Biological Process innate immune responseIEA:UniProtKB-KW
Biological Process positive regulation of interferon-gamma productionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of interleukin-17 productionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process T cell activationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process T-helper 17 cell lineage commitmentManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 22-226
Helical: 227-247
Cytoplasmic: 248-331
PTM
Phosphorylation in NK cells upon engagment by SLAMF6-expressing target cells is leading to receptor activation.
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For research use only. Not intended for any clinical use.

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