Mouse Anti-SLAMF7 Recombinant Antibody (CBFYC-3120) (CBMAB-C3197-FY)

Name: Mouse Anti-SLAMF7 Recombinant Antibody (CBFYC-3120)
SKU: CBMAB-C3197-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBFYC-3120

Application

WB, IHC

Immunogen

Recombinant protein of human SLAMF7 (NP_067004) produced in HEK293T cell

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SLAM Family Member 7

Introduction

SLAMF7 mediates activating or inhibitory effects in NK cells, depending whether cells express or not the adaptor EAT-2.

Entrez Gene ID

57823

UniProt ID

Q9NQ25

Alternative Names

SLAM Family Member 7; Membrane Protein FOAP-12; CD2 Subset 1; Protein 19A; CRACC; CS1; Novel LY9 (Lymphocyte Antigen 9) Like Protein; CD2-Like Receptor Activating Cytotoxic Cells

Function

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418).
Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536).
In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity).
May play a role in lymphocyte adhesion (PubMed:11802771).
In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines (PubMed:23695528).
Isoform 3 does not mediate any NK cell activation.

Biological Process

Biological Process adaptive immune responseIEA:UniProtKB-KW
Biological Process cell adhesion1 PublicationNAS:UniProtKB
Biological Process natural killer cell activation1 PublicationNAS:UniProtKB
Biological Process natural killer cell mediated cytotoxicity1 PublicationNAS:UniProtKB
Biological Process T cell activationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Membrane

Topology

Extracellular: 23-226
Helical: 227-247
Cytoplasmic: 248-335

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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