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SLAMF7

C3a is an anaphylatoxin released during activation of the complement system. The protein encoded by this gene is an orphan G protein-coupled receptor for C3a. Binding of C3a by the encoded receptor activates chemotaxis, granule enzyme release, superoxide anion production, and bacterial opsonization.

Full Name

SLAM Family Member 7

Function

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418).
Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536).
In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity).
May play a role in lymphocyte adhesion (PubMed:11802771).
In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines (PubMed:23695528).
Isoform 3 does not mediate any NK cell activation.

Biological Process

Biological Process adaptive immune responseIEA:UniProtKB-KW
Biological Process cell adhesion1 PublicationNAS:UniProtKB
Biological Process natural killer cell activation1 PublicationNAS:UniProtKB
Biological Process natural killer cell mediated cytotoxicity1 PublicationNAS:UniProtKB
Biological Process T cell activationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Membrane

Topology

Extracellular: 23-226
Helical: 227-247
Cytoplasmic: 248-335

Anti-SLAMF7 antibodies

Mouse Anti-SLAMF7 Recombinant Antibody (CBXS-2705) (CBMAB-S5456-CQ)

SDS

Target: SLAMF7

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXS-2705

Application*: E, IF

Rat Anti-SLAMF7 (AA 22-224) Recombinant Antibody (CBXS-0422) (CBMAB-S3373-CQ)

SDS

Target: SLAMF7

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBXS-0422

Application*: WB

Mouse Anti-SLAMF7 Recombinant Antibody (CBXS-4863) (CBMAB-S2086-CQ)

SDS

Target: SLAMF7

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-4863

Application*: WB

Mouse Anti-SLAMF7 Recombinant Antibody (CBXS-4771) (CBMAB-S1998-CQ)

SDS

Target: SLAMF7

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXS-4771

Application*: P, WB

Mouse Anti-SLAMF7 Recombinant Antibody (CBXS-4091) (CBMAB-S1348-CQ)

SDS

Target: SLAMF7

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-4091

Application*: P, WB

Mouse Anti-SLAMF7 Recombinant Antibody (CBXS-3751) (CBMAB-S1024-CQ)

SDS

Target: SLAMF7

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXS-3751

Application*: F

Rat Anti-SLAMF7 Recombinant Antibody (CBXC-1696) (CBMAB-C3487-CQ)

SDS

Target: SLAMF7

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBXC-1696

Application*: E, F

Human Anti-SLAMF7 Recombinant Antibody (CBXC-0719) (CBMAB-C1833-CQ)

SDS

Target: SLAMF7

Host: Human

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0719

Application*: F

Mouse Anti-SLAMF7 Recombinant Antibody (CBFYC-3124) (CBMAB-C3201-FY)

SDS

Target: SLAMF7

Host: Mouse

Specificity: Human

Clone: CBFYC-3124

Application*: WB, IP, F

Mouse Anti-SLAMF7 Recombinant Antibody (CBFYC-3123) (CBMAB-C3200-FY)

SDS

Target: SLAMF7

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-3123

Application*: E

Rat Anti-SLAMF7 Recombinant Antibody (CBFYC-3122) (CBMAB-C3199-FY)

SDS

Target: SLAMF7

Host: Rat

Specificity: Mouse

Clone: CBFYC-3122

Application*: F, WB

Mouse Anti-SLAMF7 Recombinant Antibody (CBFYC-3120) (CBMAB-C3197-FY)

SDS

Target: SLAMF7

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-3120

Application*: WB, IH

Mouse Anti-SLAMF7 Recombinant Antibody (CBFYC-0459) (CBMAB-C0505-FY)

SDS

Target: SLAMF7

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYC-0459

Application*: F

Mouse Anti-SLAMF7 Recombinant Antibody (CBFYC-0321) (CBMAB-C0357-FY)

SDS

Target: SLAMF7

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYC-0321

Application*: IP, F

Mouse Anti-SLAMF7 Recombinant Antibody (1G10) (CBMAB-C4127-LY)

SDS

Target: SLAMF7

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 1G10

Application*: WB, P, F

Mouse Anti-SLAMF7 Recombinant Antibody (1F1) (CBMAB-C4006-LY)

SDS

Target: SLAMF7

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1F1

Application*: WB, IH

Rat Anti-SLAMF7 Recombinant Antibody (15H35) (CBMAB-C3283-LY)

SDS

Target: SLAMF7

Host: Rat

Antibody Isotype: IgG

Specificity: Mouse

Clone: 15H35

Application*: C, WB

Mouse Anti-SLAMF7 Recombinant Antibody (14L280) (CBMAB-C3151-LY)

SDS

Target: SLAMF7

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: 14L280

Application*: F

Rat Anti-SLAMF7 Recombinant Antibody (520914) (CBMAB-C2969-LY)

SDS

Target: SLAMF7

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: 520914

Application*: F, MC

Rat Anti-SLAMF7 Recombinant Antibody (4G2) (CBMAB-C2137-LY)

SDS

Target: SLAMF7

Host: Rat

Antibody Isotype: IgG1, κ

Specificity: Mouse

Clone: 4G2

Application*: F, E, WB

Mouse Anti-SLAMF7 Recombinant Antibody (02) (CBMAB-C1669-LY)

SDS

Target: SLAMF7

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 02

Application*: E

Rabbit Anti-SLAMF7 Recombinant Antibody (003) (CBMAB-C1501-LY)

SDS

Target: SLAMF7

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: 003

Application*: E

Rabbit Anti-SLAMF7 Recombinant Antibody (002) (CBMAB-C1486-LY)

SDS

Target: SLAMF7

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 002

Application*: E

Mouse Anti-SLAMF7 Recombinant Antibody (235614) (CBMAB-C0699-LY)

SDS

Target: SLAMF7

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 235614

Application*: F, MC

Mouse Anti-SLAMF7 Recombinant Antibody (162.1) (CBMAB-C0396-LY)

SDS

Target: SLAMF7

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 162.1

Application*: F

Mouse Anti-SLAMF7 Recombinant Antibody (162) (CBMAB-C0395-LY)

SDS

Target: SLAMF7

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 162

Application*: P, F

Rabbit Anti-SLAMF7 Recombinant Antibody (E5C4M) (CBMAB-CP2460-LY)

SDS

Target: SLAMF7

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: E5C4M

Application*: WB, IH, P

Mouse Anti-SLAMF7 Recombinant Antibody (MM0200-6G17) (CBMAB-C12430-LY)

SDS

Target: SLAMF7

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: MM0200-6G17

Application*: F

Mouse Anti-SLAMF7 Recombinant Antibody (CBYY-C2132) (CBMAB-C3570-YY)

SDS

Target: SLAMF7

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBYY-C2132

Application*: F

Rabbit Anti-SLAMF7 Recombinant Antibody (CBYY-C2130) (CBMAB-C3568-YY)

SDS

Target: SLAMF7

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBYY-C2130

Application*: F

Rat Anti-SLAMF7 Recombinant Antibody (CBYY-C0282) (CBMAB-C0943-YY)

SDS

Target: SLAMF7

Host: Rat

Antibody Isotype: IgG1, κ

Specificity: Mouse

Clone: CBYY-C0282

Application*: F, E, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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