SLAMF7
C3a is an anaphylatoxin released during activation of the complement system. The protein encoded by this gene is an orphan G protein-coupled receptor for C3a. Binding of C3a by the encoded receptor activates chemotaxis, granule enzyme release, superoxide anion production, and bacterial opsonization.
Full Name
SLAM Family Member 7
Function
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418).
Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536).
In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity).
May play a role in lymphocyte adhesion (PubMed:11802771).
In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines (PubMed:23695528).
Isoform 3 does not mediate any NK cell activation.
Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536).
In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity).
May play a role in lymphocyte adhesion (PubMed:11802771).
In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines (PubMed:23695528).
Isoform 3 does not mediate any NK cell activation.
Biological Process
Biological Process adaptive immune responseIEA:UniProtKB-KW
Biological Process cell adhesion1 PublicationNAS:UniProtKB
Biological Process natural killer cell activation1 PublicationNAS:UniProtKB
Biological Process natural killer cell mediated cytotoxicity1 PublicationNAS:UniProtKB
Biological Process T cell activationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell adhesion1 PublicationNAS:UniProtKB
Biological Process natural killer cell activation1 PublicationNAS:UniProtKB
Biological Process natural killer cell mediated cytotoxicity1 PublicationNAS:UniProtKB
Biological Process T cell activationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
Topology
Extracellular: 23-226
Helical: 227-247
Cytoplasmic: 248-335
Helical: 227-247
Cytoplasmic: 248-335
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Anti-SLAMF7 antibodies
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CompareTarget: SLAMF7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: E5C4M
Application*: WB, IH, P
Target: SLAMF7
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: MM0200-6G17
Application*: F
Target: SLAMF7
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYY-C2132
Application*: F
Target: SLAMF7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYY-C2130
Application*: F
Target: SLAMF7
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 1G10
Application*: WB, P, F
Target: SLAMF7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1F1
Application*: WB, IH
Target: SLAMF7
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: 15H35
Application*: C, WB
Target: SLAMF7
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 14L280
Application*: F
Target: SLAMF7
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 520914
Application*: F, MC
Target: SLAMF7
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: 4G2
Application*: F, E, WB
Target: SLAMF7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 02
Application*: E
Target: SLAMF7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 003
Application*: E
Target: SLAMF7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 002
Application*: E
Target: SLAMF7
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 235614
Application*: F, MC
Target: SLAMF7
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 162.1
Application*: F
Target: SLAMF7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 162
Application*: P, F
Target: SLAMF7
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 7H1
Application*: E, IH, F
Target: SLAMF7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4232
Application*: IH, F
Target: SLAMF7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4826
Application*: WB, IH, F
Target: SLAMF7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-2705
Application*: E, IF
Target: SLAMF7
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXS-0422
Application*: WB
Target: SLAMF7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4863
Application*: WB
Target: SLAMF7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4771
Application*: P, WB
Target: SLAMF7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4091
Application*: P, WB
Target: SLAMF7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-3751
Application*: F
Target: SLAMF7
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXC-1696
Application*: E, F
Target: SLAMF7
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0719
Application*: F
Target: SLAMF7
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBYY-C0282
Application*: F, E, WB
Target: SLAMF7
Host: Mouse
Specificity: Human
Clone: CBFYC-3124
Application*: WB, IP, F
Target: SLAMF7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-3123
Application*: E
Target: SLAMF7
Host: Rat
Specificity: Mouse
Clone: CBFYC-3122
Application*: F, WB
Target: SLAMF7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-3120
Application*: WB, IH
Target: SLAMF7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-0459
Application*: F
Target: SLAMF7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-0321
Application*: IP, F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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