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Rat Anti-SLAMF7 Recombinant Antibody (CBFYC-3122) (CBMAB-C3199-FY)

This product is rat antibody that recognizes SLAMF7. The antibody CBFYC-3122 can be used for immunoassay techniques such as: FC, WB.
See all SLAMF7 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBFYC-3122
Application
FC, WB

Basic Information

Immunogen
Recombinant protein corresponding to mouse CRACC
Specificity
Mouse
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SLAM Family Member 7
Introduction
SLAMF7 is a protein that in humans is encoded by the SLAMF7 gene.
Entrez Gene ID
75345
UniProt ID
Q8BHK6
Alternative Names
19A; CS1; 19A24; CRACC; 4930560D03Rik
Function
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418).
Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536).
In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity).
May play a role in lymphocyte adhesion (PubMed:11802771).
In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines (PubMed:23695528).
Isoform 3 does not mediate any NK cell activation.
Biological Process
Biological Process adaptive immune responseIEA:UniProtKB-KW
Biological Process cell adhesion1 PublicationNAS:UniProtKB
Biological Process natural killer cell activation1 PublicationNAS:UniProtKB
Biological Process natural killer cell mediated cytotoxicity1 PublicationNAS:UniProtKB
Biological Process T cell activationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
Topology
Extracellular: 23-226
Helical: 227-247
Cytoplasmic: 248-335
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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