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Mouse Anti-SLC13A3 Recombinant Antibody (3A6) (CBMAB-N1061-WJ)

This product is a Mouse antibody that recognizes SLC13A3. The antibody 3A6 can be used for immunoassay techniques such as: WB, IP, ELISA.
See all SLC13A3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3A6
Application
WB, IP, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
Introduction
SLC13A3 (Solute Carrier Family 13 Member 3) is a Protein Coding gene. Diseases associated with SLC13A3 include N-Acetylglutamate Synthase Deficiency. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transporter activity and high-affinity sodium:dicarboxylate symporter activity. An important paralog of this gene is SLC13A5.
Entrez Gene ID
64849
UniProt ID
Q8WWT9
Alternative Names
NADC3, SDCT2
Function
High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, such as the citric acid cycle intermediates succinate and alpha-ketoglutarate (2-oxoglutarate), as well as other compounds including N-acetyl-L-aspartate (PubMed:10794676, PubMed:10992006, PubMed:15561973, PubMed:17426067, PubMed:17356845, PubMed:24247155, PubMed:30635937).
Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na+ for 1 divalent dicarboxylate, rendering the process electrogenic (PubMed:10794676, PubMed:10992006).
Can transport citrate in a Na+-dependent manner, recognizing the divalent form of citrate rather than the trivalent form which is normally found in blood (PubMed:10794676).
Biological Process
Biological Process anion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process citrate transportISS:ARUK-UCL
Biological Process dicarboxylic acid transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process glutathione transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process succinate transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process transport across blood-brain barrier1 PublicationNAS:ARUK-UCL
Cellular Location
Cell membrane
Involvement in disease
Leukoencephalopathy, acute reversible, with increased urinary alpha-ketoglutarate (ARLIAK):
An autosomal recessive disorder characterized by acute, reversible neurological deterioration during febrile illness. Patients exhibit reversible leukoencephalopathy and increased urinary excretion of alpha-ketoglutarate.
Topology
Cytoplasmic: 1-16
Helical: 17-37
Extracellular: 38-55
Helical: 56-76
Cytoplasmic: 77-82
Helical: 83-103
Extracellular: 104-137
Helical: 138-158
Cytoplasmic: 159-229
Helical: 230-250
Extracellular: 251-278
Helical: 279-299
Cytoplasmic: 300-336
Helical: 337-357
Extracellular: 358-372
Helical: 373-393
Cytoplasmic: 394-422
Helical: 423-443
Extracellular: 444-461
Helical: 462-482
Cytoplasmic: 483-505
Helical: 506-526
Extracellular: 527-546
Helical: 547-567
Cytoplasmic: 568-602
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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