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Mouse Anti-SLC13A3 Recombinant Antibody (CBXS-3007) (CBMAB-S5753-CQ)

This product is a mouse antibody that recognizes SLC13A3. The antibody CBXS-3007 can be used for immunoassay techniques such as: ELISA, WB.
See all SLC13A3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-3007
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa152-233 from human SLC13A3 (NP_073740) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
Introduction
Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet.
Entrez Gene ID
64849
UniProt ID
Q8WWT9
Alternative Names
Solute Carrier Family 13 Member 3; Na(+)/Dicarboxylate Cotransporter 3; NaDC-3; HNaDC3; NADC3; SDCT2; Solute Carrier Family 13 (Sodium-Dependent Dicarboxylate Transporter), Member 3; Sodium-Dependent High Affinity Dicarboxylate Transporter 3; Sodium-Dependent High-Affinity Dicarboxylate Transporter 2;
Function
High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, such as the citric acid cycle intermediates succinate and alpha-ketoglutarate (2-oxoglutarate), as well as other compounds including N-acetyl-L-aspartate (PubMed:10794676, PubMed:10992006, PubMed:15561973, PubMed:17426067, PubMed:17356845, PubMed:24247155, PubMed:30635937).
Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na+ for 1 divalent dicarboxylate, rendering the process electrogenic (PubMed:10794676, PubMed:10992006).
Can transport citrate in a Na+-dependent manner, recognizing the divalent form of citrate rather than the trivalent form which is normally found in blood (PubMed:10794676).
Biological Process
Biological Process anion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process citrate transportISS:ARUK-UCL
Biological Process dicarboxylic acid transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process glutathione transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process succinate transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process transport across blood-brain barrier1 PublicationNAS:ARUK-UCL
Cellular Location
Cell membrane
Involvement in disease
Leukoencephalopathy, acute reversible, with increased urinary alpha-ketoglutarate (ARLIAK):
An autosomal recessive disorder characterized by acute, reversible neurological deterioration during febrile illness. Patients exhibit reversible leukoencephalopathy and increased urinary excretion of alpha-ketoglutarate.
Topology
Cytoplasmic: 1-16
Helical: 17-37
Extracellular: 38-55
Helical: 56-76
Cytoplasmic: 77-82
Helical: 83-103
Extracellular: 104-137
Helical: 138-158
Cytoplasmic: 159-229
Helical: 230-250
Extracellular: 251-278
Helical: 279-299
Cytoplasmic: 300-336
Helical: 337-357
Extracellular: 358-372
Helical: 373-393
Cytoplasmic: 394-422
Helical: 423-443
Extracellular: 444-461
Helical: 462-482
Cytoplasmic: 483-505
Helical: 506-526
Extracellular: 527-546
Helical: 547-567
Cytoplasmic: 568-602
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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