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Mouse Anti-SLC13A5 Recombinant Antibody (CBXS-2946) (CBMAB-S5695-CQ)

This product is a mouse antibody that recognizes SLC13A5. The antibody CBXS-2946 can be used for immunoassay techniques such as: ELISA, IHC, WB.
See all SLC13A5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2946
Antibody Isotype
IgG1, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Partial recombinant protein corresponding to aa152-207 from human SLC13A5 (NP_808218) with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 13 (sodium-dependent citrate transporter), member 5
Introduction
This gene encodes a protein belonging to the solute carrier family 13 group of proteins. This family member is a sodium-dependent citrate cotransporter that may regulate metabolic processes. Mutations in this gene cause early infantile epileptic encephalopathy 25. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
284111
UniProt ID
Q86YT5
Alternative Names
Solute Carrier Family 13 Member 5; Solute Carrier Family 13 (Sodium-Dependent Citrate Transporter), Member 5; Na(+)/Citrate Cotransporter; NaCT; Sodium-Dependent Dicarboxylate Transporter; Na+-Coupled Citrate Transporter Protein;
Function
High-affinity sodium/citrate cotransporter that mediates the entry of citrate into cells, which is a critical participant of biochemical pathways (PubMed:12445824, PubMed:26324167, PubMed:26384929, PubMed:30054523, PubMed:33597751, PubMed:12826022).
May function in various metabolic processes in which citrate has a critical role such as energy production (Krebs cycle), fatty acid synthesis, cholesterol synthesis, glycolysis, and gluconeogenesis (PubMed:12826022).
Transports citrate into the cell in a Na+-dependent manner, recognizing the trivalent form of citrate (physiological pH) rather than the divalent form (PubMed:12445824, PubMed:26324167, PubMed:26384929, PubMed:30054523, PubMed:33597751, PubMed:12826022).
Can recognize succinate as a substrate, but its affinity for succinate is several fold lower than for citrate (PubMed:26324167).
The stoichiometry is probably 4 Na+ for each carboxylate, irrespective of whether the translocated substrate is divalent or trivalent, rendering the process electrogenic (PubMed:12445824, PubMed:12826022).
Involved in the regulation of citrate levels in the brain (By similarity).
Biological Process
Biological Process alpha-ketoglutarate transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process anion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to lithium ionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process citrate transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process fumarate transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process oxaloacetate transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process succinate transportManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane
Involvement in disease
Developmental and epileptic encephalopathy 25, with amelogenesis imperfecta (DEE25):
An autosomal recessive disease characterized by subclinical seizures appearing in the first days of life, evolving to severe epileptic disease. Affected individuals have profound or severe delayed development with lack of speech, and most patients do not acquire the ability to sit. Additional variable features include axial hypotonia, peripheral hypertonia, and abnormal involuntary movements such as dystonia and choreoathetosis. Dental abnormalities, including delayed eruption, hypodontia, tooth hypoplasia, yellow discoloration, thin enamel, and enamel chipping are observed in most patients.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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