Mouse Anti-SLC13A5 Recombinant Antibody (2G4) (CBMAB-A8169-LY)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
May function in various metabolic processes in which citrate has a critical role such as energy production (Krebs cycle), fatty acid synthesis, cholesterol synthesis, glycolysis, and gluconeogenesis (PubMed:12826022).
Transports citrate into the cell in a Na+-dependent manner, recognizing the trivalent form of citrate (physiological pH) rather than the divalent form (PubMed:12445824, PubMed:26324167, PubMed:26384929, PubMed:30054523, PubMed:33597751, PubMed:12826022).
Can recognize succinate as a substrate, but its affinity for succinate is several fold lower than for citrate (PubMed:26324167).
The stoichiometry is probably 4 Na+ for each carboxylate, irrespective of whether the translocated substrate is divalent or trivalent, rendering the process electrogenic (PubMed:12445824, PubMed:12826022).
Involved in the regulation of citrate levels in the brain (By similarity).
Biological Process anion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to lithium ionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process citrate transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process fumarate transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process oxaloacetate transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process succinate transportManual Assertion Based On ExperimentIDA:UniProtKB
An autosomal recessive disease characterized by subclinical seizures appearing in the first days of life, evolving to severe epileptic disease. Affected individuals have profound or severe delayed development with lack of speech, and most patients do not acquire the ability to sit. Additional variable features include axial hypotonia, peripheral hypertonia, and abnormal involuntary movements such as dystonia and choreoathetosis. Dental abnormalities, including delayed eruption, hypodontia, tooth hypoplasia, yellow discoloration, thin enamel, and enamel chipping are observed in most patients.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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