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Mouse Anti-SLC1A3 Monoclonal Antibody (2G7c2) (CBMAB-1110-YC)

Provided herein is a mouse monoclonal antibody against Rat SLC1A3. The antibody, clone 2G7c2, can be used for immunoassay techniques, such as ELISA, IHC-P and WB.
See all SLC1A3 antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
2G7c2
Antibody Isotype
IgG1, κ
Application
ELISA, IHC-P, WB

Basic Information

Immunogen
Synthetic peptide within Rat EAAT1 (C terminal).
Specificity
Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Solute Carrier Family 1 Member 3
Introduction
SLC1A3 is a member of a member of a high affinity glutamate transporter family, which functions in the termination of excitatory neurotransmission in central nervous system. Mutations in the SLC1A3 gene are associated with episodic ataxia, Type 6.
Entrez Gene ID
29483
UniProt ID
P24942
Alternative Names
EAAT1; GLAST; GluT-1; GLAST-1
Function
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:8123008, PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515).
Functions as a symporter that transports one amino acid molecule together with two or three Na+ ions and one proton, in parallel with the counter-transport of one K+ ion (PubMed:20477940).
Mediates Cl- flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na+ symport (PubMed:20477940).
Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity).
Biological Process
Biological Process auditory behaviorIEA:Ensembl
Biological Process cell morphogenesis involved in neuron differentiationIEA:Ensembl
Biological Process cellular response to cocaineIEA:Ensembl
Biological Process cellular sodium ion homeostasisIEA:Ensembl
Biological Process chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process chloride transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cranial nerve developmentIEA:Ensembl
Biological Process D-aspartate import across plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process gamma-aminobutyric acid biosynthetic processIEA:Ensembl
Biological Process ion transportTAS:Reactome
Biological Process L-aspartate import across plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process L-glutamate importManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process L-glutamate import across plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process L-glutamate transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process neuromuscular process controlling balanceIEA:Ensembl
Biological Process neurotransmitter transportTAS:Reactome
Biological Process neurotransmitter uptakeManual Assertion Based On ExperimentTAS:ProtInc
Biological Process positive regulation of synaptic transmissionIEA:Ensembl
Biological Process potassium ion transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to antibioticIEA:Ensembl
Biological Process response to light stimulusIEA:Ensembl
Biological Process response to woundingIEA:Ensembl
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process sensory perception of soundIEA:Ensembl
Biological Process transepithelial transportISS:ARUK-UCL
Biological Process transport across blood-brain barrierISS:ARUK-UCL
Cellular Location
Cell membrane
Involvement in disease
Episodic ataxia 6 (EA6):
A disorder characterized by episodic ataxia, seizures, migraine and alternating hemiplegia.
Topology
Cytoplasmic: 1-47
Helical: 48-68
Extracellular: 69-86
Helical: 87-108
Cytoplasmic: 109-122
Helical: 123-145
Extracellular: 146-236
Helical: 237-260
Cytoplasmic: 261-269
Helical: 270-297
Extracellular: 298-318
Helical: 319-340
Cytoplasmic: 341-345
Helical: 346-376
Extracellular: 377-385
Helical: 386-412
Cytoplasmic: 413-425
Helical: 426-459
Extracellular: 460-472
Helical: 473-494
Cytoplasmic: 495-542
PTM
Glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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