Sign in or Register   Sign in or Register
  |  

Mouse Anti-SLC24A5 Recombinant Antibody (A-6) (CBMAB-N4278-WJ)

This product is a Mouse antibody that recognizes SLC24A5. The antibody A-6 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all SLC24A5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
A-6
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Solute Carrier Family 24 Member 5
Introduction
This gene is a member of the potassium-dependent sodium/calcium exchanger family and encodes an intracellular membrane protein with 2 large hydrophilic loops and 2 sets of multiple transmembrane-spanning segments. Sequence variation in this gene has been associated with differences in skin pigmentation. [provided by RefSeq, Jul 2008]
Entrez Gene ID
283652
UniProt ID
Q71RS6
Alternative Names
Solute Carrier Family 24 Member 5; Solute Carrier Family 24 (Sodium/Potassium/Calcium Exchanger), Member 5; Oculocutaneous Albinism 6 (Autosomal Recessive); Na(+)/K(+)/Ca(2+)-Exchange Protein 5; NCKX5; JSX;
Function
Calcium, potassium:sodium antiporter that transports 1 Ca2+ and 1 K+ to the melanosome in exchange for 4 cytoplasmic Na+ (PubMed:18166528).
Involved in pigmentation, possibly by participating in ion transport in melanosomes (PubMed:16357253, PubMed:18166528).
Predominant sodium-calcium exchanger in melanocytes (PubMed:16357253, PubMed:18166528).
Biological Process
Biological Process calcium ion importManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process calcium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular calcium ion homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ion transmembrane transportManual Assertion Based On ExperimentIDA:MGI
Biological Process ion transportTAS:Reactome
Biological Process melanin biosynthetic processIEA:Ensembl
Biological Process melanocyte differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of melanin biosynthetic processIEA:Ensembl
Biological Process response to stimulusIEA:UniProtKB-KW
Cellular Location
Golgi apparatus, trans-Golgi network membrane
Melanosome
Enriched in late-stage melanosomes.
Involvement in disease
Albinism, oculocutaneous, 6 (OCA6):
A disorder characterized by a reduction or complete loss of melanin in the skin, hair and eyes. Patients show reduced or lacking pigmentation often accompanied by eye symptoms such as photophobia, strabismus, moderate to severe visual impairment, and nystagmus.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-SLC24A5 Recombinant Antibody (A-6)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare