Mouse Anti-SLC24A5 Recombinant Antibody (A-6) (CBMAB-N4278-WJ)

Name: Mouse Anti-SLC24A5 Recombinant Antibody (A-6)
SKU: CBMAB-N4278-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

A-6

Application

WB, IP, IF, ELISA

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Solute Carrier Family 24 Member 5

Introduction

This gene is a member of the potassium-dependent sodium/calcium exchanger family and encodes an intracellular membrane protein with 2 large hydrophilic loops and 2 sets of multiple transmembrane-spanning segments. Sequence variation in this gene has been associated with differences in skin pigmentation. [provided by RefSeq, Jul 2008]

Entrez Gene ID

283652

UniProt ID

Q71RS6

Alternative Names

Solute Carrier Family 24 Member 5; Solute Carrier Family 24 (Sodium/Potassium/Calcium Exchanger), Member 5; Oculocutaneous Albinism 6 (Autosomal Recessive); Na(+)/K(+)/Ca(2+)-Exchange Protein 5; NCKX5; JSX;

Function

Calcium, potassium:sodium antiporter that transports 1 Ca2+ and 1 K+ to the melanosome in exchange for 4 cytoplasmic Na+ (PubMed:18166528).
Involved in pigmentation, possibly by participating in ion transport in melanosomes (PubMed:16357253, PubMed:18166528).
Predominant sodium-calcium exchanger in melanocytes (PubMed:16357253, PubMed:18166528).

Biological Process

Biological Process calcium ion importManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process calcium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular calcium ion homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ion transmembrane transportManual Assertion Based On ExperimentIDA:MGI
Biological Process ion transportTAS:Reactome
Biological Process melanin biosynthetic processIEA:Ensembl
Biological Process melanocyte differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of melanin biosynthetic processIEA:Ensembl
Biological Process response to stimulusIEA:UniProtKB-KW

Cellular Location

Golgi apparatus, trans-Golgi network membrane
Melanosome
Enriched in late-stage melanosomes.

Involvement in disease

Albinism, oculocutaneous, 6 (OCA6):
A disorder characterized by a reduction or complete loss of melanin in the skin, hair and eyes. Patients show reduced or lacking pigmentation often accompanied by eye symptoms such as photophobia, strabismus, moderate to severe visual impairment, and nystagmus.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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