Mouse Anti-SLC25A11 Recombinant Antibody (CBXS-2171) (CBMAB-S4934-CQ)

Name: Mouse Anti-SLC25A11 Recombinant Antibody (CBXS-2171)
SKU: CBMAB-S4934-CQ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBXS-2171

Application

WB, IP, IF, ELISA

Specificity

Mouse, Rat, Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11

Introduction

The oxoglutarate/malate carrier transports 2-oxoglutarate across the inner membranes of mitochondria in an electroneutral exchange for malate or other dicarboxylic acids (summary by Iacobazzi et al., 1992 [PubMed 1457818]).

Entrez Gene ID

Human	8402
Mouse	67863
Rat	64201

UniProt ID

Human	Q02978
Mouse	Q9CR62
Rat	P97700

Alternative Names

Solute Carrier Family 25 Member 11; Solute Carrier Family 25 (Mitochondrial Carrier; Oxoglutarate Carrier), Member 11; SLC20A4; OGCP; Solute Carrier Family 20 (Oxoglutarate Carrier), Member 4; Mitochondrial 2-Oxoglutarate/Malate Carrier Protein; OGC;

Function

Catalyzes the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate. Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity. Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity).
Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (PubMed:21448454).
Involved in the regulation of apoptosis (By similarity).
Helps protect from cytotoxic-induced apoptosis by modulating glutathione levels in mitochondria (By similarity).

Biological Process

Biological Process malate transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process oxaloacetate transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process phosphate ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process succinate transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sulfate transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process thiosulfate transportManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Mitochondrion inner membrane

Involvement in disease

Paragangliomas 6 (PGL6):
An autosomal dominant tumor predisposition syndrome characterized by adult-onset development of paragangliomas, neural crest tumors usually derived from the chromoreceptor tissue of a paraganglion. Paragangliomas can develop at various body sites, including the head, neck, thorax and abdomen. Some of the tumors may secrete biologically active normetanephrine, resulting in secondary hypertension. PGL6 patients are at high risk for metastatic disease.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-SLC25A11 Recombinant Antibody (3G4) (CAT#: CBMAB-A8190-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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