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Mouse Anti-SLC25A11 Recombinant Antibody (CBXS-4916) (CBMAB-S2138-CQ)

This product is a mouse antibody that recognizes SLC25A11. The antibody CBXS-4916 can be used for immunoassay techniques such as: ELISA, IHC-P, WB.
See all SLC25A11 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4916
Antibody Isotype
IgG1, κ
Application
ELISA, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
Introduction
The oxoglutarate/malate carrier transports 2-oxoglutarate across the inner membranes of mitochondria in an electroneutral exchange for malate or other dicarboxylic acids (summary by Iacobazzi et al., 1992 [PubMed 1457818]).
Entrez Gene ID
8402
UniProt ID
Q02978
Alternative Names
Solute Carrier Family 25 Member 11; Solute Carrier Family 25 (Mitochondrial Carrier; Oxoglutarate Carrier), Member 11; SLC20A4; OGCP; Solute Carrier Family 20 (Oxoglutarate Carrier), Member 4; Mitochondrial 2-Oxoglutarate/Malate Carrier Protein; OGC;
Function
Catalyzes the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate. Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity. Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity).
Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (PubMed:21448454).
Involved in the regulation of apoptosis (By similarity).
Helps protect from cytotoxic-induced apoptosis by modulating glutathione levels in mitochondria (By similarity).
Biological Process
Biological Process malate transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process oxaloacetate transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process phosphate ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process succinate transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sulfate transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process thiosulfate transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Mitochondrion inner membrane
Involvement in disease
Paragangliomas 6 (PGL6):
An autosomal dominant tumor predisposition syndrome characterized by adult-onset development of paragangliomas, neural crest tumors usually derived from the chromoreceptor tissue of a paraganglion. Paragangliomas can develop at various body sites, including the head, neck, thorax and abdomen. Some of the tumors may secrete biologically active normetanephrine, resulting in secondary hypertension. PGL6 patients are at high risk for metastatic disease.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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