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Mouse Anti-SLC26A5 Recombinant Antibody (CBXS-2782) (CBMAB-S5533-CQ)

This product is a mouse antibody that recognizes SLC26A5. The antibody CBXS-2782 can be used for immunoassay techniques such as: ELISA, WB.
See all SLC26A5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2782
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant protein corresponding to aa645-742 from human SLC26A5 (NP_945350) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 26, member 5 (prestin)
Introduction
This gene encodes a member of the SLC26A/SulP transporter family. The protein functions as a molecular motor in motile outer hair cells (OHCs) of the cochlea, inducing changes in cell length that act to amplify sound levels. The transmembrane protein is an incomplete anion transporter, and does not allow anions to cross the cell membrane but instead undergoes a conformational change in response to changes in intracellular Cl- levels that results in a change in cell length. The protein functions at microsecond rates, which is several orders of magnitude faster than conventional molecular motor proteins. Mutations in this gene are potential candidates for causing neurosensory deafness. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
375611
UniProt ID
P58743
Alternative Names
Solute Carrier Family 26 Member 5; Solute Carrier Family 26 (Anion Exchanger), Member 5; Prestin (Motor Protein); PRES; Deafness, Neurosensory, Autosomal Recessive, 61; Prestin; DFNB61;
Function
Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site (By similarity).
Biological Process
Biological Process cochlea developmentIEA:Ensembl
Biological Process fructose transmembrane transportIEA:Ensembl
Biological Process negative regulation of ion transmembrane transportIEA:Ensembl
Biological Process positive regulation of cell motilityIEA:Ensembl
Biological Process positive regulation of cell sizeIEA:Ensembl
Biological Process regulation of cell shapeIEA:UniProtKB-KW
Biological Process regulation of membrane potentialIEA:Ensembl
Biological Process response to auditory stimulusIEA:Ensembl
Biological Process response to ischemiaIEA:Ensembl
Biological Process response to potassium ionIEA:Ensembl
Biological Process response to salicylic acidIEA:Ensembl
Biological Process response to saltIEA:Ensembl
Biological Process response to thyroid hormoneIEA:Ensembl
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process sensory perception of soundManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Lateral wall of outer hair cells.
Involvement in disease
Deafness, autosomal recessive, 61 (DFNB61):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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