Rat Slc26a5 ELISA Kit (V2LY-0626-LY1019)

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Tested Data
Datasheet
SDS
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Basic Information

Sensitivity
0.56 ng/mL
Detection Range
1-400 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Rat
Assay Type
Sandwich
Reactivity
Rat
Assay Time
1.5 h
Molecule Mass
81.3 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
solute carrier family 26, member 5 (prestin)
Function
Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site (By similarity).
Biological Process
Biological Process cochlea developmentIEA:Ensembl
Biological Process fructose transmembrane transportIEA:Ensembl
Biological Process negative regulation of ion transmembrane transportIEA:Ensembl
Biological Process positive regulation of cell motilityIEA:Ensembl
Biological Process positive regulation of cell sizeIEA:Ensembl
Biological Process regulation of cell shapeIEA:UniProtKB-KW
Biological Process regulation of membrane potentialIEA:Ensembl
Biological Process response to auditory stimulusIEA:Ensembl
Biological Process response to ischemiaIEA:Ensembl
Biological Process response to potassium ionIEA:Ensembl
Biological Process response to salicylic acidIEA:Ensembl
Biological Process response to saltIEA:Ensembl
Biological Process response to thyroid hormoneIEA:Ensembl
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process sensory perception of soundManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Lateral wall of outer hair cells.
Involvement in disease
Deafness, autosomal recessive, 61 (DFNB61):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human SLC26A5 ELISA Kit (CAT#: V2LY-0626-LY4087)

Related Products

Human SLC26A5 ELISA Kit (CAT#: V2LY-0626-LY4087)

Mouse Anti-SLC26A5 Recombinant Antibody (CBXS-2782) (CAT#: CBMAB-S5533-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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