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Mouse Anti-SLC2A4 Recombinant Antibody (2E11NB) (CBMAB-G1183-LY)

This product is antibody recognizes SLC2A4. The antibody 2E11NB immunoassay techniques such as: WB.
See all SLC2A4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2E11NB
Antibody Isotype
IgG1, κ
Application
WB

Basic Information

Immunogen
Partial recombinant human protein (between amino acids 300-350) [UniProt P14672]
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Solute Carrier Family 2 Member 4
Introduction
This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008]
Entrez Gene ID
6517
UniProt ID
P14672
Alternative Names
Solute Carrier Family 2 Member 4; Solute Carrier Family 2 (Facilitated Glucose Transporter); Member 4; Glucose Transporter Type 4; Insulin-Responsive; GLUT-4; GLUT4; Solute Carrier Family 2; Facilitated Glucose Transporter Member 4; Insulin-Responsive Glucose Transporter Type 4;
Function
Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell.
Biological Process
Biological Process amylopectin biosynthetic processIEA:Ensembl
Biological Process brown fat cell differentiationIEA:Ensembl
Biological Process carbohydrate metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process cellular response to hypoxiaIEA:Ensembl
Biological Process cellular response to insulin stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to osmotic stressIEA:Ensembl
Biological Process cellular response to tumor necrosis factorIEA:Ensembl
Biological Process glucose homeostasisManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process glucose import1 PublicationNAS:BHF-UCL
Biological Process glucose import in response to insulin stimulusISS:UniProtKB
Biological Process glucose transmembrane transportISS:UniProtKB
Biological Process learning or memoryISS:ARUK-UCL
Biological Process long-term memoryISS:ARUK-UCL
Biological Process monosaccharide transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of brain-derived neurotrophic factor receptor signaling pathwayISS:ARUK-UCL
Biological Process regulation of synaptic vesicle budding from presynaptic endocytic zone membraneIEA:Ensembl
Biological Process response to ethanolIEA:Ensembl
Biological Process short-term memoryISS:ARUK-UCL
Biological Process transport across blood-brain barrier1 PublicationNAS:ARUK-UCL
Cellular Location
Cell membrane
Endomembrane system
Cytoplasm, perinuclear region
Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized (PubMed:8300557).
The dileucine internalization motif is critical for intracellular sequestration (PubMed:8300557).
Insulin stimulation induces translocation to the cell membrane (By similarity)
Involvement in disease
Diabetes mellitus, non-insulin-dependent (NIDDM):
A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
PTM
Sumoylated.
Palmitoylated (PubMed:28057756).
Palmitoylation by ZDHHC7 controls the insulin-dependent translocation of GLUT4 to the plasma membrane (PubMed:28057756).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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