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Mouse Anti-SLC2A4 Recombinant Antibody (CBT2996) (V2LY-0625-LY960)


See all SLC2A4 antibodies
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Tested Data
Mouse Anti-SLC2A4 Recombinant Antibody (CBT2996) (V2LY-0625-LY960) in WB
Mouse Anti-SLC2A4 Recombinant Antibody (CBT2996) (V2LY-0625-LY960) in WB
Mouse Anti-SLC2A4 Recombinant Antibody (CBT2996) (V2LY-0625-LY960) in WB
Mouse Anti-SLC2A4 Recombinant Antibody (CBT2996) (V2LY-0625-LY960) in WB
Mouse Anti-SLC2A4 Recombinant Antibody (CBT2996) (V2LY-0625-LY960) in WB
Mouse Anti-SLC2A4 Recombinant Antibody (CBT2996) (V2LY-0625-LY960) in WB
Mouse Anti-SLC2A4 Recombinant Antibody (CBT2996) (V2LY-0625-LY960) in IF
Mouse Anti-SLC2A4 Recombinant Antibody (CBT2996) (V2LY-0625-LY960) in IF
Mouse Anti-SLC2A4 Recombinant Antibody (CBT2996) (V2LY-0625-LY960) in IF
Mouse Anti-SLC2A4 Recombinant Antibody (CBT2996) (V2LY-0625-LY960) in IF
Mouse Anti-SLC2A4 Recombinant Antibody (CBT2996) (V2LY-0625-LY960) in FC
Mouse Anti-SLC2A4 Recombinant Antibody (CBT2996) (V2LY-0625-LY960) in FC
Mouse Anti-SLC2A4 Recombinant Antibody (CBT2996) (V2LY-0625-LY960) in IHC
Mouse Anti-SLC2A4 Recombinant Antibody (CBT2996) (V2LY-0625-LY960) in IHC
Mouse Anti-SLC2A4 Recombinant Antibody (CBT2996) (V2LY-0625-LY960) in IHC
Mouse Anti-SLC2A4 Recombinant Antibody (CBT2996) (V2LY-0625-LY960) in IHC
Mouse Anti-SLC2A4 Recombinant Antibody (CBT2996) (V2LY-0625-LY960) in ELISA
Mouse Anti-SLC2A4 Recombinant Antibody (CBT2996) (V2LY-0625-LY960) in ELISA

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBT2996
Antibody Isotype
IgG2b
Application
WB, IHC, ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human SLC2A4 (AA: 224-353 ) expressed in E. Coli.
Host Species
Mouse
Specificity
Human, Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ICC1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Preservative
Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
6517
Function
Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell.
Biological Process
Biological Process amylopectin biosynthetic processIEA:Ensembl
Biological Process brown fat cell differentiationIEA:Ensembl
Biological Process carbohydrate metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process cellular response to hypoxiaIEA:Ensembl
Biological Process cellular response to insulin stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to osmotic stressIEA:Ensembl
Biological Process cellular response to tumor necrosis factorIEA:Ensembl
Biological Process glucose homeostasisManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process glucose import1 PublicationNAS:BHF-UCL
Biological Process glucose import in response to insulin stimulusISS:UniProtKB
Biological Process glucose transmembrane transportISS:UniProtKB
Biological Process learning or memoryISS:ARUK-UCL
Biological Process long-term memoryISS:ARUK-UCL
Biological Process monosaccharide transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of brain-derived neurotrophic factor receptor signaling pathwayISS:ARUK-UCL
Biological Process regulation of synaptic vesicle budding from presynaptic endocytic zone membraneIEA:Ensembl
Biological Process response to ethanolIEA:Ensembl
Biological Process short-term memoryISS:ARUK-UCL
Biological Process transport across blood-brain barrier1 PublicationNAS:ARUK-UCL
Cellular Location
Cell membrane
Endomembrane system
Cytoplasm, perinuclear region
Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized (PubMed:8300557).
The dileucine internalization motif is critical for intracellular sequestration (PubMed:8300557).
Insulin stimulation induces translocation to the cell membrane (By similarity)
Involvement in disease
Diabetes mellitus, non-insulin-dependent (NIDDM):
A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
PTM
Sumoylated.
Palmitoylated (PubMed:28057756).
Palmitoylation by ZDHHC7 controls the insulin-dependent translocation of GLUT4 to the plasma membrane (PubMed:28057756).
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For research use only. Not intended for any clinical use.

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