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Mouse Anti-SLC38A1 Recombinant Antibody (CBXS-0469) (CBMAB-S3419-CQ)

This product is a mouse antibody that recognizes SLC38A1. The antibody CBXS-0469 can be used for immunoassay techniques such as: WB, IHC-P, IF.
See all SLC38A1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBXS-0469
Antibody Isotype
IgG1
Application
WB, IHC-P, IF

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.09% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Solute Carrier Family 38 Member 1
Introduction
Amino acid transporters play essential roles in the uptake of nutrients, production of energy, chemical metabolism, detoxification, and neurotransmitter cycling. SLC38A1 is an important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea. Glutamine serves as a precursor for the synaptic transmitter, glutamate (Gu et al., 2001 [PubMed 11325958]).
Entrez Gene ID
Human81539
Mouse105727
Rat170567
UniProt ID
HumanQ9H2H9
MouseQ8K2P7
RatQ9JM15
Alternative Names
Solute Carrier Family 38 Member 1; System A Amino Acid Transporter 1; System N Amino Acid Transporter 1; N-System Amino Acid Transporter 2; Amino Acid Transporter A1; SNAT1; NAT2;
Function
Symporter that cotransports short-chain neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:20599747, PubMed:10891391).
The transport is elctrogenic, pH dependent and driven by the Na+ electrochemical gradient (PubMed:10891391).
Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis (By similarity).
May also contributes to amino acid transport in placental trophoblasts (PubMed:20599747).
Also regulates synaptic plasticity (PubMed:12388062).
Biological Process
Biological Process amino acid importISS:UniProtKB
Biological Process amino acid transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process amino acid transportTAS:Reactome
Biological Process female pregnancyIEA:Ensembl
Biological Process gamma-aminobutyric acid biosynthetic processISS:UniProtKB
Biological Process glutamine metabolic processISS:UniProtKB
Biological Process glutamine transportISS:UniProtKB
Biological Process L-alpha-amino acid transmembrane transportISS:ARUK-UCL
Biological Process neurotransmitter uptakeTAS:Reactome
Biological Process neutral amino acid transportISS:ARUK-UCL
Biological Process positive regulation of L-glutamine import across plasma membraneISS:UniProtKB
Biological Process regulation of synaptic plasticityISS:UniProtKB
Biological Process regulation of synaptic transmission, GABAergicISS:UniProtKB
Biological Process transport across blood-brain barrier2 PublicationsNAS:ARUK-UCL
Cellular Location
Cell membrane
Restricted to the somatodendritic compartment of neurons. Found in the cellular processes of neurons in the developing brain.
PTM
N-glycosylation plays an important role in the L-glutamine transport.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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