Mouse Anti-SLC38A1 Recombinant Antibody (S104-32) (CBMAB-S0014-CQ)

Name: Mouse Anti-SLC38A1 Recombinant Antibody (S104-32)
SKU: CBMAB-S0014-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

S104-32

Application

WB, IHC, IF

Immunogen

Fusion protein amino acids 1- 63 of rat SNAT1

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Solute Carrier Family 38 Member 1

Introduction

Amino acid transporters play essential roles in the uptake of nutrients, production of energy, chemical metabolism, detoxification, and neurotransmitter cycling. SLC38A1 is an important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea. Glutamine serves as a precursor for the synaptic transmitter, glutamate (Gu et al., 2001 [PubMed 11325958]).

Entrez Gene ID

Human	81539
Mouse	105727
Rat	170567

UniProt ID

Human	Q9H2H9
Mouse	Q8K2P7
Rat	Q9JM15

Alternative Names

Solute Carrier Family 38 Member 1; System A Amino Acid Transporter 1; System N Amino Acid Transporter 1; N-System Amino Acid Transporter 2; Amino Acid Transporter A1; SNAT1; NAT2;

Function

Symporter that cotransports short-chain neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:20599747, PubMed:10891391).
The transport is elctrogenic, pH dependent and driven by the Na+ electrochemical gradient (PubMed:10891391).
Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis (By similarity).
May also contributes to amino acid transport in placental trophoblasts (PubMed:20599747).
Also regulates synaptic plasticity (PubMed:12388062).

Biological Process

Biological Process amino acid importISS:UniProtKB
Biological Process amino acid transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process amino acid transportTAS:Reactome
Biological Process female pregnancyIEA:Ensembl
Biological Process gamma-aminobutyric acid biosynthetic processISS:UniProtKB
Biological Process glutamine metabolic processISS:UniProtKB
Biological Process glutamine transportISS:UniProtKB
Biological Process L-alpha-amino acid transmembrane transportISS:ARUK-UCL
Biological Process neurotransmitter uptakeTAS:Reactome
Biological Process neutral amino acid transportISS:ARUK-UCL
Biological Process positive regulation of L-glutamine import across plasma membraneISS:UniProtKB
Biological Process regulation of synaptic plasticityISS:UniProtKB
Biological Process regulation of synaptic transmission, GABAergicISS:UniProtKB
Biological Process transport across blood-brain barrier2 PublicationsNAS:ARUK-UCL

Cellular Location

Cell membrane
Restricted to the somatodendritic compartment of neurons. Found in the cellular processes of neurons in the developing brain.

PTM

N-glycosylation plays an important role in the L-glutamine transport.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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